CCR4 antagonist 3
Based on 1 Customer Validation
CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM).
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 1957-01-3
- Formula: C14H12N2S
- Molecular Weight:240.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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[125I]-TARC-CCR4 1.7 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
1.7 μM
Compound: 1
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Displacement of [125I]TARC from CCR4 expressed in human CEM cell line
Displacement of [125I]TARC from CCR4 expressed in human CEM cell line
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[PMID: 16497499] |
| CCRF-CEM | IC50 |
3 μM
Compound: 1
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Displacement of [125I]MDC from CCR4 expressed in human CEM cell line
Displacement of [125I]MDC from CCR4 expressed in human CEM cell line
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[PMID: 16497499] |
| CCRF-CEM | IC50 |
6.4 μM
Compound: 1
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Inhibition of TARC-mediated CEM cell migration
Inhibition of TARC-mediated CEM cell migration
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[PMID: 16497499] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:0.5 mg/kg for IV; 2 mg/kg for PO
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Administration:IV and PO; single dosage
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Result:Exhibited a high clearance of 4.2 L/h/kg and a short half-life of 0.4 h, and the oral bioavailability of 2%.
Chemical Information
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CAS No. 1957-01-3
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Appearance Solid
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Molecular Weight 240.32
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Formula C14H12N2S
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Color Off-white to light yellow
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SMILES
CC1=CSC(NC2=C3C=CC=CC3=CC=C2)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (260.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1611 mL | 20.8056 mL | 41.6112 mL | 104.0280 mL |
| 5 mM | 0.8322 mL | 4.1611 mL | 8.3222 mL | 20.8056 mL | |
| 10 mM | 0.4161 mL | 2.0806 mL | 4.1611 mL | 10.4028 mL | |
| 15 mM | 0.2774 mL | 1.3870 mL | 2.7741 mL | 6.9352 mL | |
| 20 mM | 0.2081 mL | 1.0403 mL | 2.0806 mL | 5.2014 mL | |
| 25 mM | 0.1664 mL | 0.8322 mL | 1.6644 mL | 4.1611 mL | |
| 30 mM | 0.1387 mL | 0.6935 mL | 1.3870 mL | 3.4676 mL | |
| 40 mM | 0.1040 mL | 0.5201 mL | 1.0403 mL | 2.6007 mL | |
| 50 mM | 0.0832 mL | 0.4161 mL | 0.8322 mL | 2.0806 mL | |
| 60 mM | 0.0694 mL | 0.3468 mL | 0.6935 mL | 1.7338 mL | |
| 80 mM | 0.0520 mL | 0.2601 mL | 0.5201 mL | 1.3003 mL | |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4161 mL | 1.0403 mL |
CCR4 antagonist 3 Related Classifications
HY-147385 Related Classifications
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