CCR4 antagonist 3

Name: CCR4 antagonist 3
Brand: MedChemExpress
SKU: HY-147385
Rating: 4.5 (1 reviews)

Cat. No.: HY-147385 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC₅₀ value of 1.7 μM for [¹²⁵I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM).

For research use only. We do not sell to patients.

CCR4 antagonist 3 Chemical Structure

CAS No. : 1957-01-3

Size	Price	Stock	Quantity
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 880	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1380	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

[¹²⁵I]-TARC-CCR4

1.7 μM (IC₅₀)

In Vivo

CCR4 antagonist 3 (compound 1) (0.5 mg/kg for IV; 2 mg/kg for PO; single dosage) exhibits a high clearance, short half-life and low oral bioavailability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[1]
Dosage:	0.5 mg/kg for IV; 2 mg/kg for PO
Administration:	IV and PO; single dosage
Result:	Exhibited a high clearance of 4.2 L/h/kg and a short half-life of 0.4 h, and the oral bioavailability of 2%.

Molecular Weight

240.32

Formula

C₁₄H₁₂N₂S

CAS No.

1957-01-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=CSC(NC2=C3C=CC=CC3=CC=C2)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (260.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1611 mL	20.8056 mL	41.6112 mL
5 mM	0.8322 mL	4.1611 mL	8.3222 mL
10 mM	0.4161 mL	2.0806 mL	4.1611 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (252 KB) HNMR (248 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1611 mL	20.8056 mL	41.6112 mL	104.0280 mL
	5 mM	0.8322 mL	4.1611 mL	8.3222 mL	20.8056 mL
	10 mM	0.4161 mL	2.0806 mL	4.1611 mL	10.4028 mL
	15 mM	0.2774 mL	1.3870 mL	2.7741 mL	6.9352 mL
	20 mM	0.2081 mL	1.0403 mL	2.0806 mL	5.2014 mL
	25 mM	0.1664 mL	0.8322 mL	1.6644 mL	4.1611 mL
	30 mM	0.1387 mL	0.6935 mL	1.3870 mL	3.4676 mL
	40 mM	0.1040 mL	0.5201 mL	1.0403 mL	2.6007 mL
	50 mM	0.0832 mL	0.4161 mL	0.8322 mL	2.0806 mL
	60 mM	0.0694 mL	0.3468 mL	0.6935 mL	1.7338 mL
	80 mM	0.0520 mL	0.2601 mL	0.5201 mL	1.3003 mL
	100 mM	0.0416 mL	0.2081 mL	0.4161 mL	1.0403 mL