1957-01-3
Chemical Structure
CCR4 antagonist 3
- CAS No.: 1957-01-3
- Formula:C14H12N2S
- Molecular Weight:240.32
IUPAC Name: 4-methyl-N-(naphthalen-1-yl)thiazol-2-amine
InChIKey: QNKLFDFMOINNIW-UHFFFAOYSA-N
SMILES: CC1=CSC(NC2=C3C=CC=CC3=CC=C2)=N1
Biological Activity: CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM)[1].
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CCR4 antagonist 3 | 99.94% | CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM). | ||||||||||||||||||||
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Keywords
