1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. C-021 dihydrochloride

C-021 dihydrochloride 

Cat. No.: HY-103364A Purity: >99.0%
Handling Instructions

C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM.

For research use only. We do not sell to patients.

C-021 dihydrochloride Chemical Structure

C-021 dihydrochloride Chemical Structure

CAS No. : 1784252-84-1

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10 mM * 1 mL in DMSO USD 624 In-stock
Estimated Time of Arrival: December 31
1 mg USD 175 In-stock
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10 mg USD 895 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].

IC50 & Target[1]

CCR4

 

In Vitro

The in vitro oxidative metabolic stability of C-021 (Compound 1b) is evaluated by measuring the rate of drug consumption in human liver microsomes (HML), thus providing intrinsic clearance values (CLint). C-021 exhibits CLint value of 17,377 mL/h/kg[1].

In Vivo

The potency of C-021 (Compound 1b) is evident after subcutaneous administration in the murine oxazolone-induced contact hypersensitivity test, a known model of acute skin inflammation. When C-021 is administered orally, however, very little inhibition is observed[1].

Molecular Weight

540.57

Formula

C₂₇H₄₃Cl₂N₅O₂

CAS No.

1784252-84-1

SMILES

COC1=CC2=NC(N3CCC(N4CCCCC4)CC3)=NC(NC5CCCCCC5)=C2C=C1OC.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

C-021C021C 021CCRCC chemokine receptorFunctionalchemotaxisclearancesubcutaneousadministrationInhibitorinhibitorinhibit

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Product name:
C-021 dihydrochloride
Cat. No.:
HY-103364A
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