NECTIN3 - nectin cell adhesion molecule 3 Gene

Also Known as PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25945

About NECTIN3

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:111,071,816-111,194,170 (from NCBI)

This gene has 11 transcripts (splice variants), 285 orthologues and 14 paralogues. Broad expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 22 other tissues.

Summary

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with Other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

NECTIN3 Products (3)

mRNA Protein Name
NM_001243286.2 NP_001230215.1 nectin-3 isoform 2 precursor
NM_001243288.2 NP_001230217.1 nectin-3 isoform 3
NM_015480.3 NP_056295.1 nectin-3 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
12438620 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22902367 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19011627 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECTIN3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (64 - 166)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (175 - 256)

Ig_2

Ig_2: Immunoglobulin domain (287 - 348)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 549 a.a.
Protein Preferred Names Protein Names

nectin-3

  • nectin 3

NECTIN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NECTIN3 Q9NQS3 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
NECTIN3 Q9NQS3 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
NECTIN3 Q9NQS3 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
NECTIN3 Q9NQS3 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
NECTIN3 Q9NQS3 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra
NECTIN3 Q9NQS3 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
Intra
NECTIN3 Q9NQS3 RGS20 Homo sapiens O76081
Y2H Prey Pooling
25416956
Intra
NECTIN3 Q9NQS3 RGS20 Homo sapiens O76081
Y2H Array
25416956
Intra
NECTIN3 Q9NQS3 NECTIN1 Homo sapiens Q15223
FACS
12011057
Intra
NECTIN3 Q9NQS3 NECTIN1 Homo sapiens Q15223
Protein Array
21982860
Intra
NECTIN3 Q9NQS3 NECTIN1 Homo sapiens Q15223
Anti Tag CoIP
33961781
Intra
NECTIN3 Q9NQS3 TIGIT Homo sapiens Q495A1
Protein Array
21982860
Intra
NECTIN3 Q9NQS3 NECTIN2 Homo sapiens Q92692
Anti Tag CoIP
33961781
Intra
NECTIN3 Q9NQS3 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
NECTIN3 Q9NQS3 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NECTIN3 Proteins

Cat. No. Product Name Accession Purity
HY-P7782 Nectin-3/CD113 Protein, Human (309a.a, HEK293, His) Q9NQS3-1 (G58-P366) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73306 Nectin-3/CD113 Protein, Human (400a.a, HEK293, His) Q9NQS3-1/NP_056295.1(G58-D400) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78180 Nectin-3/CD113 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NQS3-1 (G58-D400) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78496 Nectin-3/CD113 Protein, Human (HEK293, His-Avi) Q9NQS3 (G58-D400) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78919 Nectin-3/CD113 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q9NQS3-1 (G58-D400) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

  • Orofacial Cleft 7

  • Zlotogora-Ogur Syndrome

  • CLPED1

  • Ectodermal Dysplasia, Margarita Island Type

  • Ed4

  • Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

  • Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

  • Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

  • Ectodermal Dysplasia 4

  • Ectodermal Dysplasia Margarita Type

  • Ectodermal Dysplasia, Type 4

  • Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

  • Margarita Type Of Ectodermal Dysplasia

  • Zlotogora-Zilberman-Tenenbaum Syndrome

  • Ectd4

  • Ectodermal Dysplasia 4, Hair/Nail Type

  • EDMI

  • Ectodermal Dysplasia Type 4

  • Margarita Island Ectodermal Dysplasia

  • Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

  • Non-Syndromic Orofacial Cleft 7

  • OFC7

  • Non-Syndromic Cleft Lip/Palate 7

  • Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Clostridium Difficile Colitis

  • Pseudomembranous Colitis

  • Colitis Pseudomembranous

  • Enterocolitis, Pseudomembranous

  • Pseudomembranous Enterocolitis

  • Clostridium Difficile Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09176 NECTIN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NECTIN3 VGNC VGNC:102787
Rattus norvegicus NECTIN3 RGD RGD:1309516
Mus musculus NECTIN3 MGD MGI:1930171
Macaca mulatta NECTIN3 VGNC VGNC:83928
Bos taurus NECTIN3 VGNC VGNC:106835
Others NECTIN3 NCBI