Nectin-3/CD113 Protein, Human (400a.a, HEK293, His)

Nectin-3/CD113, a versatile cell adhesion protein, plays a pivotal role in mediating cell-cell interactions through heterophilic trans-binding with nectin-like proteins or nectins, exemplified by its interaction with NECTIN2 at Sertoli-spermatid junctions. This trans-interaction with PVR triggers the activation of CDC42 and RAC small G proteins, mediated by common signaling molecules such as SRC and RAP1. Beyond its involvement in adherens junctions and synapses, Nectin-3/CD113 induces endocytosis-mediated down-regulation of PVR from the cell surface, leading to a reduction in cell movement and proliferation. Furthermore, it contributes to the morphology of the ciliary body and forms cis- and trans-homodimers, as well as trans-heterodimers with various proteins, including NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1, and IGSF4. The interaction between NECTIN1 and NECTIN3 at pre- and postsynaptic sites initiates the formation of puncta adherentia junctions between axons and dendrites. Additionally, Nectin-3/CD113 binds with low affinity to TIGIT and interacts with AFDN, establishing a connection with the actin cytoskeleton.