NECTIN3 - nectin cell adhesion molecule 3 Gene

Homo sapiens

Also known as PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3

Gene ID: 25945 | Gene type: protein coding

About NECTIN3

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:111,071,816-111,194,170 (from NCBI)

This gene has 11 transcripts (splice variants), 285 orthologues and 14 paralogues. Broad expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 22 other tissues.

Summary

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

NECTIN3 Products(3)

mRNA	Protein	Name
NM_001243286.2	NP_001230215.1	nectin-3 isoform 2 precursor
NM_001243288.2	NP_001230217.1	nectin-3 isoform 3
NM_015480.3	NP_056295.1	nectin-3 isoform 1 precursor

NECTIN3 Protein Structure

V-set

C2-set_2

Ig_2

0
100
200
300
400
500
549 a.a.

Protein Preferred Names

Protein Names

nectin-3

nectin 3

Recombinant NECTIN3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7782	Nectin-3/CD113 Protein, Human (309a.a, HEK293, His)	Q9NQS3 (G58-P366)	≥95%
HY-P73306	Nectin-3/CD113 Protein, Human (400a.a, HEK293, His)	Q9NQS3 (M1-D400)	≥95%
HY-P78180	Nectin-3/CD113 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9NQS3 (G58-D400)	≥95%
HY-P78496	Nectin-3/CD113 Protein, Human (HEK293, His-Avi)	Q9NQS3 (G58-D400)	≥95%
HY-P78919	Nectin-3/CD113 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9NQS3 (G58-D400)	≥95%

Related Diseases

Diseases

Alias

Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7	Zlotogora-Ogur Syndrome
CLPED1	Ectodermal Dysplasia, Margarita Island Type
Ed4	Cleft Lip-Palate-Ectodermal Dysplasia Syndrome
Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome	Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate
Ectodermal Dysplasia 4	Ectodermal Dysplasia Margarita Type
Ectodermal Dysplasia, Type 4	Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly
Margarita Type Of Ectodermal Dysplasia	Zlotogora-Zilberman-Tenenbaum Syndrome
Ectd4	Ectodermal Dysplasia 4, Hair/Nail Type
EDMI	Ectodermal Dysplasia Type 4
Margarita Island Ectodermal Dysplasia	Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate
Non-Syndromic Orofacial Cleft 7	OFC7
Non-Syndromic Cleft Lip/Palate 7	Non-Syndromic Cleft Lip With Or Without Cleft Palate 7

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09176	NECTIN3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NECTIN3	VGNC	VGNC:102787
Rattus norvegicus	NECTIN3	RGD	RGD:1309516
Mus musculus	NECTIN3	MGD	MGI:1930171
Macaca mulatta	NECTIN3	VGNC	VGNC:83928
Bos taurus	NECTIN3	VGNC	VGNC:106835

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