ATG-022 Antibody
ATG-022 Antibody is a humanized monoclonal antibody targeting Claudin 18.2 (CLDN 18.2). ATG-022 Antibody binds with VcMMAE (HY-15575) to form an Antibody-Drug Conjugate (ADC). ATG-022 Antibody can be used for the research of advanced/metastatic solid tumors and gastric cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human
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CLDN18.2 |
ATG-022 Antibody potently reduces viability of CLDN18.2-overexpressing CHOK1 cells with an IC50 of 5-7 nM after conjugating with VcMMAE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ATG-022 Antibody (3-10 mg/kg; i.v.; two doses every two weeks) induces tumor regression at 10 mg/kg in low CLDN18.2-expressing gastric cancer PDX models, while 3 mg/kg shows no antitumor activity after conjugating with VcMMAE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Immunocompromised mice[2]
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Dosage:1 mg/kg; 3 mg/kg; 10 mg/kg
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Administration:i.v.; two doses every two weeks
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Result:Induced 35.41% tumor growth inhibition (%TGI) at 1 mg/kg.
Induced 71.56% TGI at 3 mg/kg.
Induced tumor regression at 10 mg/kg.
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Animal Model:Immunocompromised mice[2]
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Dosage:3 mg/kg; 10 mg/kg
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Administration:i.v.; two doses every two weeks
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Result:Did not inhibit tumor growth at 3 mg/kg.
Induced tumor regression at 10 mg/kg.
CLDN18.2
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATG-022 Antibody Related Classifications
HY-P992316 Related Classifications
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