2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. bPiDDB

bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs.

For research use only. We do not sell to patients.

bPiDDB Chemical Structure

bPiDDB Chemical Structure

CAS No. : 525596-66-1

Size Price Stock Quantity
5 mg USD 70 In-stock
10 mg USD 120 In-stock
25 mg USD 250 In-stock
50 mg USD 420 In-stock
100 mg USD 700 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

bPiDDB Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs[1].

In Vivo

bPiDDB (peripherally administered) inhibits nicotine-evoked dopamine (DA) release in nucleus accumbens and decrease intravenous nicotine self-administration in rats[1].
bPiDDB is brain bioavailable following peripheral administration and is transported actively by the blood-brain barrier choline transporter into the central compartment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

514.38

Formula

C24H38Br2N2
CAS No.
Appearance

Oil

Color

Off-white to light yellow

SMILES

CC1=C[N+](CCCCCCCCCCCC[N+]2=CC=CC(C)=C2)=CC=C1.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (194.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9441 mL 9.7204 mL 19.4409 mL
5 mM 0.3888 mL 1.9441 mL 3.8882 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9441 mL 9.7204 mL 19.4409 mL 48.6022 mL
5 mM 0.3888 mL 1.9441 mL 3.8882 mL 9.7204 mL
10 mM 0.1944 mL 0.9720 mL 1.9441 mL 4.8602 mL
15 mM 0.1296 mL 0.6480 mL 1.2961 mL 3.2401 mL
20 mM 0.0972 mL 0.4860 mL 0.9720 mL 2.4301 mL
25 mM 0.0778 mL 0.3888 mL 0.7776 mL 1.9441 mL
30 mM 0.0648 mL 0.3240 mL 0.6480 mL 1.6201 mL
40 mM 0.0486 mL 0.2430 mL 0.4860 mL 1.2151 mL
50 mM 0.0389 mL 0.1944 mL 0.3888 mL 0.9720 mL
60 mM 0.0324 mL 0.1620 mL 0.3240 mL 0.8100 mL
80 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6075 mL
100 mM 0.0194 mL 0.0972 mL 0.1944 mL 0.4860 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

bPiDDB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

bPiDDB525596-66-1nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
bPiDDB
Cat. No.:
HY-107674
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.