Erzotabart
Based on 1 Customer Validation
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 2430792-01-9
- Molecular Weight:145.056 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
CD38
Erzotabart targets cell surface glycoprotein CD-38 and carries the E430G mutation. Erzotabart promotes antibody hexamer formation through the E430G mutation in the Fc segment, and exhibits immunomodulating and antineoplastic activities[2].
Erzotabart induces complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), trogocytosis, inhibits the cyclase activity of CD38, and increases the hydrolase activity with EC50s of 0.044 µg/mL, 0.29 ng/mL, 2.719-5.779 ng/mL, 8.79 ng/mL, 0.419 µg/mL and 0.335 µg/mL, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ly12638 xenograft mouse models[3]
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Dosage:0.1-10 mg/kg
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Administration:iv, once weekly for 3 weeks
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Result:Inhibited tumor growth.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Loaded Erzotabart on AHC2 biosensor, can bind CD38 Protein, Human (HEK293, C-His, HY-P70731A) with an affinity constant of 1.209E-09 M as determined in BLI assay. -
Flow Cytometry analysis of Raji cells labelling CD38 (red) with Erzotabart (anti-CD38) (HY-P990037). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 2430792-01-9
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Appearance Liquid
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Molecular Weight 145.056 kDa
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Color Colorless to light yellow
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SMILES
[Erzotabart]
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Synonyms
GEN3014
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)