Cntf - ciliary neurotrophic factor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12803

Summary

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and CNTF sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and CNTF has been observed in both human and mouse. [provided by RefSeq, Aug 2008]

Cntf Products (1)

mRNA Protein Name
NM_170786.2 NP_740756.1 ciliary neurotrophic factor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within muscle organ morphogenesis IGI
IGI: Inferred from genetic interaction
15716414 MGI
acts upstream of or within negative regulation of photoreceptor cell differentiation IDA
IDA: Inferred from direct assay
15207851 MGI
acts upstream of or within neuron development IGI
IGI: Inferred from genetic interaction
15716414 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15051883 MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15207851 MGI
acts upstream of or within regulation of retinal cell programmed cell death IDA
IDA: Inferred from direct assay
11747369 MGI
acts upstream of retinal rod cell differentiation IDA
IDA: Inferred from direct assay
15207851 MGI
acts upstream of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15207851 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15207851 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ciliary neurotrophic factor

Recombinant Cntf Proteins

Cat. No. Product Name Accession Purity
HY-P7147 CNTF Protein, Mouse P51642 (A2-M198) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74242 CNTF Protein, Mouse (His) Q544D1 (A2-M198) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74242AF Animal-Free CNTF Protein, Mouse (His) P51642 (M1-M198) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0889 Glycylglycine 99.90% Unkown
HY-D0889R Glycylglycine (Standard) 99.91% Unkown
HY-RS02923 CNTF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16555 Cntf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22988 Cntf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W040074 Glycylglycine hydrochloride hydrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cntf NCBI NCBI:1270