MAPK8IP1 - mitogen-activated protein kinase 8 interacting protein 1 Gene

Also Known as IB1; JIP1; JIP-1; PRKM8IP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9479

About MAPK8IP1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,885,651-45,906,465 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 54.8), testis (RPKM 11.7) and 5 other tissues.

Summary

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced Apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

MAPK8IP1 Products (1)

mRNA Protein Name
NM_005456.4 NP_005447.1 C-Jun-amino-terminal kinase-interacting protein 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP-kinase scaffold activity IPI
IPI: Inferred from physical interaction
11238452 GOA
enables kinesin binding IPI
IPI: Inferred from physical interaction
11238452 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11517249 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10574993 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK8IP1 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (495 - 543)

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (567 - 700)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
Protein Preferred Names Protein Names

C-Jun-amino-terminal kinase-interacting protein 1

  • IB-1

MAPK8IP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAPK8IP1 Q9UQF2 MAPK8 Homo sapiens P45983
Pull Down
18286207
Intra
MAPK8IP1 Q9UQF2 MAPK8 Homo sapiens P45983
GMS
18286207
Intra
MAPK8IP1 Q9UQF2 MAPK8 Homo sapiens P45983
Anti Tag CoIP
33961781
Intra
MAPK8IP1 Q9UQF2 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
MAPK8IP1 Q9UQF2 MAP3K7 Homo sapiens O43318
Pull Down
18286207
Intra
MAPK8IP1 Q9UQF2 MAP3K7 Homo sapiens O43318
GMS
18286207
Intra
MAPK8IP1 Q9UQF2 MAP2K7 Homo sapiens O14733
Pull Down
16840345
Intra
MAPK8IP1 Q9UQF2 MAP2K7 Homo sapiens O14733
GMS
18286207
Intra
MAPK8IP1 Q9UQF2 MAP2K7 Homo sapiens O14733
Pull Down
18286207
Intra
MAPK8IP1 Q9UQF2 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
MAPK8IP1 Q9UQF2 APP Homo sapiens P05067
Y2H
11724784
Intra
MAPK8IP1 Q9UQF2 APP Homo sapiens P05067
FRET
11724784
Intra
MAPK8IP1 Q9UQF2 APP Homo sapiens P05067
Pull Down
11724784
Cross
MAPK8IP1 Q9UQF2 App Mus musculus P12023
Y2H
11517249
Cross
MAPK8IP1 Q9UQF2 App Mus musculus P12023
CoIP
11517249
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Papillary Squamous Carcinoma

  • Papillary Epidermoid Carcinoma

  • Papillary Squamous Cell Carcinoma
Cervix Erosion

  • Erosion Of Cervix

  • Uterine Cervical Erosion
Cervical Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Cervix

  • Adenosquamous Cell Carcinoma Of The Cervix Uteri
Lymphocele

  • Lymph Cyst

  • Lymphocele Adverse Event
Cervix Small Cell Carcinoma

  • Small Cell Carcinoma Of The Cervix

  • Small Cell Carcinoma Of The Cervix Uteri
Ischemia

  • Acute Coronary Syndrome
Vaginal Cancer

  • Malignant Neoplasm Of Vagina

  • Vaginal Neoplasms

  • Malignant Tumor Of Vagina

  • Malignant Vaginal Tumor

  • Neoplasm Of Vagina

  • Vagina Neoplasm

  • Vaginal Tumor

  • Vaginal Carcinoma

  • Vaginal Malignant Epithelial Tumor

  • Vaginal Neoplasm

  • Malignant Vaginal Neoplasm

  • Vagina Carcinoma

  • Vaginal Neoplasia

  • Cancer Of Vagina

  • Malignant Tumour Of Vagina

  • Carcinoma Of Vagina

  • Primary Malignant Neoplasm Of Vagina

  • Vagina Wall Cancer

  • Vaginal Wall Cancer
Hemometra

  • Hematometra
Cervical Clear Cell Adenocarcinoma

  • Clear Cell Carcinoma Of The Cervix Uteri
Cervix Endometriosis

  • Endometriosis Of Cervix

  • Cervical Endometriosis
Sigmoid Disease

  • Sigmoid Diseases
Cervical Incompetence

  • Uterine Cervical Incompetence
Vaginal Discharge
Cervical Adenoid Basal Carcinoma
Cervical Carcinosarcoma

  • Cervical Malignant Mixed Mesodermal Mullerian Tumor

  • Cervical Malignant Mixed Mullerian Tumor

  • Cervical Mixed Epithelial And Mesenchymal Neoplasm
Cervical Mucinous Adenocarcinoma
Isthmus Cancer
Endocervical Carcinoma

  • Carcinoma Of Endocervix

  • Carcinoma Of The Endocervix
Radiation Cystitis

  • Irradiation Cystitis
Cervix Carcinoma

  • Cancer Of Cervix

  • Carcinoma Of Cervix

  • Carcinoma Cervix Uteri

  • Carcinoma Of The Cervix Uteri
Cervical Polyp

  • Cervix Adenomatous Polyp
Uterus Carcinoma In Situ
Anal Canal Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Anal Canal
Cervix Uteri Carcinoma In Situ

  • Carcinoma In Situ Of Cervix

  • Carcinoma In Situ Of Uterine Cervix

  • Cervical Intraepithelial Neoplasia

  • Carcinoma Of Cervix Stage 0

  • Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

  • Cervix Ca In Situ

  • Cin Iii

  • Cin Iii - Carcinoma In Situ Of Cervix

  • Cin Iii - Severe Dyskaryosis

  • Severe Dysplasia Of Cervix

  • Severe Dysplasia Of The Cervix Uteri

  • Squamous Intraepithelial Neoplasia, Grade Iii

  • Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Cancerophobia

  • Cancer Phobia

  • Fear Of Getting Cancer
Adenosquamous Carcinoma

  • Adenosquamous Cell Carcinoma

  • Mixed Adenocarcinoma And Squamous Carcinoma

  • Carcinoma Adenosquamous

  • Carcinoma, Adenosquamous
Ovarian Melanoma
Nosophobia
Botryoid Rhabdomyosarcoma

  • Sarcoma Botryoides

  • Botryoid Sarcoma

  • Botryoid-Type Embryonal Rhabdomyosarcoma
Adenocarcinoma In Situ
Cervical Adenocarcinoma

  • Adenocarcinoma Cervix Uteri

  • Adenocarcinoma Of Cervix

  • Adenocarcinoma Of The Uterine Cervix

  • Adenocarcinoma Of The Cervix Uteri
Endocervical Adenocarcinoma

  • Endocervical Carcinoma
Endometrial Small Cell Carcinoma
Cervix Disease

  • Uterine Cervical Diseases

  • Cervix Disorders

  • Cervix Diseases
Vaginal Disease

  • Vaginal Diseases
Cervical Adenosarcoma

  • Cervical Muellerian Adenosarcoma

  • Cervical Mullerian Adenosarcoma
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08124 MAPK8IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22065 Mapk8ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MAPK8IP1 VGNC VGNC:49920
Mus musculus MAPK8IP1 MGD MGI:1309464
Felis catus MAPK8IP1 VGNC VGNC:82019
Rattus norvegicus MAPK8IP1 RGD RGD:70937
Bos taurus MAPK8IP1 VGNC VGNC:31224
Macaca mulatta MAPK8IP1 VGNC VGNC:74650
Others MAPK8IP1 NCBI