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Cat. No.: HY-N19824

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Koninginin D

Koninginin D is a potent antifungal agent that can be isolated from fungi including Trichoderma applanatum. Koninginin D inhibits growth of various fungal species including Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana and so on. Koninginin D can be used for the research of fungal infection.

For research use only. We do not sell to patients.

CAS No.: 119903-56-9
Formula: C₁₆H₂₆O₅
Molecular Weight:298.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Koninginin D Chemical Structure

CAS No.: 119903-56-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Koninginin D inhibits the growth of Listeria monocytogenes, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Edwardsiella megii, and Vibrio alginolyticus with minimum inhibitory concentrations of 256 μg/mL, 128 μg/mL, and 64 μg/mL, respectively^[3].
Koninginin D inhibits the growth of Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana, Pythium middletonii, Fusarium oxysporum, Phytophthora cinnamomi, Rhizoctonia solani at 10 μg/disk and Ceratobasidium cornigerum with an MIC of 64 μg/mL^[3].
Koninginin D (50 μM) exhibits significant cytotoxic activity against A549, HeLa, and HepG2 cancer cell lines^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 119903-56-9
Molecular Weight 298.37
Formula C₁₆H₂₆O₅
SMILES

O[C@H]1C2=C([C@@H](CCC2=O)O)O[C@](C1)([H])[C@@H](O)CCCCCC
Structure Classification
- Antibiotics
Initial Source
- Microorganisms
Trichoderma koningii
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen L, et al. Trichodermatides E and F from fungus Trichoderma applanatum. J Asian Nat Prod Res. 2019 Jul;21(7):659-665. [Content Brief]

[2]. Song F, et al. Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii. J Nat Prod. 2010;73(5):806-810. [Content Brief]

[3]. José C. I. Silva, et al. Koninginins and Related Octaketides from Trichoderma and Other Fungi:
Chemical Diversity and Biological Activities. J. Braz. Chem. Soc. 2025, 36, 11, e-20250110, 1-24.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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