Mps1-IN-7
Based on 1 Customer Validation
Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50= 0.11 μM, JNK2 IC50=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM,respectively.
For research use only. We do not sell to patients.
- Purity: 98.55%
- CAS No.: 1578244-34-4
- Formula: C24H29N7O
- Molecular Weight:431.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.020 μM (MSP1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAL-27 | GI50 |
0.23 μM
Compound: 34h
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Antiproliferative activity against human CAL27 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human CAL27 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| CAL-51 | GI50 |
0.068 μM
Compound: 34h
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Antiproliferative activity against human CAL51 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human CAL51 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| HCT-116 | GI50 |
0.16 μM
Compound: 34h
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Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| HCT-116 | IC50 |
0.059 μM
Compound: 34h
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Inhibition of wild type Myc-ectopic MPS1 (unknown origin) expressed in human HCT116 cells assessed as autophosphorylation at Thr33/Ser37 after 2 hrs by electrochemiluminescence assay in presence of MG132
Inhibition of wild type Myc-ectopic MPS1 (unknown origin) expressed in human HCT116 cells assessed as autophosphorylation at Thr33/Ser37 after 2 hrs by electrochemiluminescence assay in presence of MG132
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[PMID: 27055065] |
| MIA PaCa-2 | GI50 |
0.25 μM
Compound: 34h
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Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| PNT2 | GI50 |
3.95 μM
Compound: 34h
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Antiproliferative activity against human PNT2 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human PNT2 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| RMG-I | GI50 |
0.11 μM
Compound: 34h
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Antiproliferative activity against human RMG-1 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human RMG-1 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| Sf9 | IC50 |
0.011 μM
Compound: 34h
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Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins
Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins
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[PMID: 27055065] |
| Sf9 | IC50 |
0.02 μM
Compound: 34h
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Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins in presence of 1 mM ATP
Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins in presence of 1 mM ATP
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[PMID: 27055065] |
| SW-620 | GI50 |
0.065 μM
Compound: 34h
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Antiproliferative activity against human SW620 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
Chemical Information
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CAS No. 1578244-34-4
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Appearance Solid
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Molecular Weight 431.53
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Formula C24H29N7O
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Color White to yellow
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SMILES
CC(C)(C)[C@@H](NC1=NC=CC2=CN=C(NC3=CC=C(C4=CN(C)N=C4)C=C3OC)N=C21)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (57.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3173 mL | 11.5867 mL | 23.1734 mL | 57.9334 mL |
| 5 mM | 0.4635 mL | 2.3173 mL | 4.6347 mL | 11.5867 mL | |
| 10 mM | 0.2317 mL | 1.1587 mL | 2.3173 mL | 5.7933 mL | |
| 15 mM | 0.1545 mL | 0.7724 mL | 1.5449 mL | 3.8622 mL | |
| 20 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.8967 mL | |
| 25 mM | 0.0927 mL | 0.4635 mL | 0.9269 mL | 2.3173 mL | |
| 30 mM | 0.0772 mL | 0.3862 mL | 0.7724 mL | 1.9311 mL | |
| 40 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.4483 mL | |
| 50 mM | 0.0463 mL | 0.2317 mL | 0.4635 mL | 1.1587 mL |
Mps1-IN-7 Related Classifications
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