Galacardins A and B, new glycopeptide antibiotics

  • J Antibiot (Tokyo). 1992 Mar;45(3):297-305. doi: 10.7164/antibiotics.45.297.
M Takeuchi  1 ,  S Takahashi ,  R Enokita ,  Y Sakaida ,  H Haruyama ,  T Nakamura ,  T Katayama ,  M Inukai
Affiliations
  • 1. Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
PMID: 1577657 DOI: 10.7164/antibiotics.45.297
Abstract

A strain of actinomycetes identified as Saccharothrix sp. SANK 64289 was found to produce new Antibiotics, galacardins A and B. Their physico-chemical properties showed that they were new members of Glycopeptide antibiotics. They were structurally related to beta-avoparcin but differed from it only in sugar composition. Though beta-avoparcin does not contain galactose, galacardins A and B did contain two and one moles of galactose, respectively. They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus Infection in mice.

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