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Cat. No.: HY-180403

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TLX agonist 3

TLX agonist 3 is a potent and selective tailless homolog (TLX, NR2E1) agonist with an EC₅₀ of 0.25 μM and a K_d of 1.6 μM). TLX agonist 3 shows high selectivity over related nuclear receptors, and promotes TLX oligomerization with an EC₅₀ of 5.0 μM. TLX agonist 3 can be used for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 3032232-47-3
Formula: C₂₅H₂₃F₃N₄O₂
Molecular Weight:468.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

TLX agonist 3 Chemical Structure

CAS No.: 3032232-47-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

TLX

0.25 μM (EC₅₀)

TLX

1.6 μM (Kd)

In Vitro

TLX agonist 3 (compound 10) (2.5-20 μM; 22 h) enhances TLX oligomerization in a concentration-dependent manner in homogeneous time-resolved fluorescence resonance energy transfer\n(HTRF)-based assay^[1].
TLX agonist 3 activates full-length human TLX in HEK293 cells with an EC₅₀ of 0.7 μM^[1].
TLX agonist 3 (3 µM; 8 h) induces SIRT1 expression without altering TLX levels in T98G human astrocyte cells cells^[1].
TLX agonist 3 (10 µM; 0-60 min) shows favorable microsomal stability (t_1/2 = 142 min) in rat liver microsomes^[1].
TLX agonist 3 (up to 10 µM; 24 h) shows no pronounced cytotoxic effects in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

T98G human astrocyte cells
Concentration:

3 μM
Incubation Time:

8 h
Result:

Induced expression of the TLX-regulated gene SIRT1 but did not alter TLX levels.

Chemical Information

CAS No. 3032232-47-3
Molecular Weight 468.48
Formula C₂₅H₂₃F₃N₄O₂
SMILES

O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2C=NC(=C2)C)C=3C=C(N=C4C=CC=CC43)OCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Faudone G, et al. Design of a Potent TLX Agonist by Rational Fragment Fusion. J Med Chem. 2022;65(3):2288-2296. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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