Cat. No.: HY-B2219

Stearic acid

22 Cited Publications

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Based on 22 publication(s) in Google Scholar

Stearic acid is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Stearic acid can be used in the study of cardiovascular and metabolic diseases.

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Pureté: 99.87%
CAS No.: 57-11-4
Formule: C₁₈H₃₆O₂
Masse moléculaire:284.48

Stockage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Stearic acid Chemical Structure

CAS No.: 57-11-4

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (22)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	IC₅₀	>200 μM Compound: R9C1 Table4	Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay	[PMID: 20405849]
HT-29	IC₅₀	>200 μM Compound: R9C1 Table4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 20405849]

In Vitro

Stearic acid (50 μM; 48 h) increases apoptosis of 3T3L1 preadipocytes, decreases the expression of cIAP2 and Bcl2, and increases the expression of Bax^[1].
Stearic acid (0-200 μM; 48 h) shows a dose-dependent cytotoxicity to 3T3L1 preadipocytes starting at 35 μM and reaching a maximum at 100 μM, and increases caspase-3 activity in preadipocytes after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Stearic acid (17% stearic acid/3% safflower oil diet, p.o.; ad libitum; 18 weeks and 3 days) reduces bone mineral density, abdominal fat content, and serum glucose concentration, and increases serum monocyte chemoattractant protein-1 levels in female athymic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 57-11-4
Appearance Solid
Masse moléculaire 284.48
Formule C₁₈H₃₆O₂
Color White to off-white
SMILES

CCCCCCCCCCCCCCCCCC(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (22)

All Cell Imaging/StainingIFRT-PCRBio/Physico-chemical Assay

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Bioact Mater

Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus. [Abstract]

2023 Nov 9:33:85-99. PMID: 38024229

Stearic acid purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 9:33:85-99. [Abstract]

Stearic acid (300 μM; 24 h). Analysis of fatty acid production in PDLCs after exosomes treatment with or without C75 application by liquid chromatography-mass spectrometry.
J Adv Res

Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy. [Abstract]

2025 Aug:74:589-607. PMID: 39353532
Cell Death Dis

Elovl7 sensitizes podocytes to ferroptosis in podocytopathy by elongating polyunsaturated fatty acids. [Abstract]

2025 Nov 24;16(1):857. PMID: 41285716

Stearic acid purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Nov 24;16(1):857. [Abstract]

Stearic acid (SA; 80 μM; 24 h). Representative images of oil red staining in γ-LA, OA or SA stimulated MPC5 cells.
Cell Death Dis

Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition. [Abstract]

2020 Sep 15;11(9):756. PMID: 32934217
Cell Death Dis

Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?. [Abstract]

2019 May 28;10(6):416. PMID: 31138790
Proc Natl Acad Sci U S A

Ancestral and local adaptation contribute to dispersal out of the Qinghai-Tibet Plateau in a bumblebee. [Abstract]

2026 Feb 10;123(6):e2513080122. PMID: 41587327
Free Radic Biol Med

Ferroptosis signaling promotes the release of misfolded proteins via exosomes to rescue ER stress in hepatocellular carcinoma. [Abstract]

2023 Jun:202:110-120. PMID: 36997100
J Transl Med

Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma. [Abstract]

2025 Sep 24;23(1):1011. PMID: 40993737
Cell Rep

A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]

2025 Nov 25;44(11):116496. PMID: 41166305
Chem Biol Interact

Mechanisms and targeted prevention of chronic pancreatitis-acinar to ductal metaplasia caused by a low concentration of di-(2-ethylhexyl)-phthalate. [Abstract]

2025 Sep 26:111758. PMID: 41016453

Stearic acid purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758. [Abstract]

Stearic acid (SA; 10 μM; 6 h). IF staining analysis of CK19.

Stearic acid purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758. [Abstract]

Stearic acid (SA; 10 μM; 6 h). Triplicate qPCR analysis of CTGF.

Stearic acid purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758. [Abstract]

Stearic acid (SA; 10 μM; 6 h). Intracellular ROS levels.
Nanoscale Adv

Dexamethasone-loaded lipid-polymeric nanoparticles to improve therapy for cisplatin-induced sensorineural hearing loss. [Abstract]

2025 Nov 21. PMID: 41278499
FASEB J

SREBP-1-mediated lipogenesis confers resistance to ferroptosis and improves endothelial injury. [Abstract]

2024 Jul 15;38(13):e23806. PMID: 38970404
Mol Nutr Food Res

Consumption of Saturated Fatty Acids-Rich Lard Benefits Recovery of Experimental Arthritis by Activating PPAR-γ. [Abstract]

2023 Jan;67(2):e2200429. PMID: 36433679
J Biol Chem

STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth. [Abstract]

2024 Jun;300(6):107351. PMID: 38718868
BMC Cancer

APOL4-mediated intracellular cholesterol trafficking is essential for glioblastoma cell growth. [Abstract]

2025 May 21;25(1):906. PMID: 40399861
Pathol Res Pract

Sphingosine kinase 1 regulates lipid metabolism to promote progression of kidney renal clear cell carcinoma. [Abstract]

2023 Aug:248:154641. PMID: 37467634
J Pharm Biomed Anal

Identification of new small molecule inhibitors of PD-1/PD-L1 interaction by a comprehensive ligand fishing system. [Abstract]

2025 Nov 23:270:117281. PMID: 41308584
Biofuel Bioprod Bior

2025 Sep 3;19(5):1378-1399.
Plant Pathol

2025 Dec 30.
Eur J Lipid Sci Technol

2023 Feb 25.
Reprod Domest Anim

6-Gingerol and Astaxanthin Mitigate the Effects of Stearic Acid in Pig Oocyte Maturation. [Abstract]

2024 Nov;59(11):e14746. PMID: 39582146

Solvant et solubilité

In Vitro:

Ethanol : 25 mg/mL (87.88 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5152 mL

17.5759 mL

35.1519 mL

5 mM

0.7030 mL

3.5152 mL

7.0304 mL

10 mM

0.3515 mL

1.7576 mL

3.5152 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Shen MC et al. Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. PLoS One. 2014 Sep 15;9(9):e104083. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	3.5152 mL	17.5759 mL	35.1519 mL	87.8796 mL
	5 mM	0.7030 mL	3.5152 mL	7.0304 mL	17.5759 mL
	10 mM	0.3515 mL	1.7576 mL	3.5152 mL	8.7880 mL
	15 mM	0.2343 mL	1.1717 mL	2.3435 mL	5.8586 mL
	20 mM	0.1758 mL	0.8788 mL	1.7576 mL	4.3940 mL
	25 mM	0.1406 mL	0.7030 mL	1.4061 mL	3.5152 mL
	30 mM	0.1172 mL	0.5859 mL	1.1717 mL	2.9293 mL
	40 mM	0.0879 mL	0.4394 mL	0.8788 mL	2.1970 mL
	50 mM	0.0703 mL	0.3515 mL	0.7030 mL	1.7576 mL
	60 mM	0.0586 mL	0.2929 mL	0.5859 mL	1.4647 mL
	80 mM	0.0439 mL	0.2197 mL	0.4394 mL	1.0985 mL

Keywords

Stearic acid

22 Cited Publications

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Stearic acid

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Publications Citing Use of MedChemExpress (MCE) Stearic acid

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Publications (22)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Stearic acid Related Classifications

HY-B2219 Related Classifications