country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182400

Copy Link Print Information

AGI-25696

AGI-25696 is an orally active ethionine adenosyltransferase 2A (MAT2A) inhibitor with an IC₅₀ of 97 nM. AGI-25696 reduces intracellular SAM levels in cancer cells. AGI-25696 inhibits tumor growth in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts. AGI-25696 can be used for the research of mtap-deleted pancreatic cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2201065-84-9
Formule: C₂₈H₂₀N₄O
Masse moléculaire:428.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AGI-25696 Chemical Structure

CAS No.: 2201065-84-9

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

MAT2A

97 nM (IC₅₀)

In Vitro

AGI-25696 potently inhibits purified recombinant MAT2A homodimer with an IC₅₀ of 97 nM^[1].
AGI-25696 (72 h) dose-dependently reduces intracellular SAM levels in HCT116 MTAP-null cells with an IC₅₀ of 150 nM and 84% maximal inhibition after 72 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AGI-25696 (300 mg/kg; p.o.; once daily; 33 days) achieves a tumor growth inhibition of 67.8% in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts, with no observed body weight loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice bearing subcutaneous KP4 MTAP-null
xenografts^[1]
Dosage:

300 mg/kg
Administration:

p.o.; once daily; 33 days
Result:

Achieved a tumor growth inhibition (TGI) of 67.8% relative to vehicle-treated controls.
Caused no adverse effects on mouse body weight during the 33-day study.

Chemical Information

CAS No. 2201065-84-9
Masse moléculaire 428.48
Formule C₂₈H₂₀N₄O
SMILES

O=C1C(C2=CC3=C(N=CC=C3)C=C2)=C(C)NC4=C(C(C5=CC=CC=C5)=NN14)C6=CC=CC=C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Konteatis Z, et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J Med Chem. 2021;64(8):4430-4449. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis