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Cat. No.: HY-162108

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Antitumor agent-128

Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells.

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CAS No.: 1942910-49-7
Formule: C₁₈H₉N₃O₂
Masse moléculaire:299.28

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitumor agent-128 Chemical Structure

CAS No.: 1942910-49-7

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.25 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 38169246]
A549	IC₅₀	0.34 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38169246]
A549	IC₅₀	0.34 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38169246]
A549	IC₅₀	0.43 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 38169246]
HCT-116	IC₅₀	25.22 μM Compound: 1a	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38169246]
MDA-MB-231	IC₅₀	3.54 μM Compound: 1a	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38169246]

Chemical Information

CAS No. 1942910-49-7
Masse moléculaire 299.28
Formule C₁₈H₉N₃O₂
SMILES

O=C1N2C(C(C3=C2C=CC=C3)=O)=NC4=NC5=CC=CC=C5C=C41
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bao-Long Hou, et al. Natural products fragment-based design and synthesis of a novel pentacyclic ring system as potential MAPK inhibitor. Bioorg Med Chem Lett. 2023 Dec 31:99:129598. [Content Brief]

Calculators

Calculateur de molarité

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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