Antitumor agent-133
Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC50=17.13 μM) and Huh7 (IC50=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins.
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- Formule: C27H24Br2N4O8
- Masse moléculaire:692.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AML12 | IC50 |
>100 μM
Compound: 4d
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Antiproliferative activity against mouse AML12 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against mouse AML12 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| H22 | IC50 |
16.89 μM
Compound: 4d
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Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| HepG2 | IC50 |
>100 μM
Compound: 4d
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| Huh-7 | IC50 |
8.27 μM
Compound: 4d
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Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| MHCC97H | IC50 |
>100 μM
Compound: 4d
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Antiproliferative activity against human MHCC97H cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against human MHCC97H cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
Antitumor agent-133 (0-100 μM, 48h) exhibits antitumor activities with IC50 values of 17.13 μM (Huh1) and 8.27μM (Huh7) and selectivity towards cancer cells [1].
Antitumor agent-133 (0-100 μM, 48h) induces cancer cell autophagy through regulating the expressions of LC3B (I and II), ATG5 and p62[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Huh1 xenograft model in NCG mice [1]
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Dosage:i.p., 15 mg/kg, once every two days for 14 days
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Administration:intraperitoneal injection
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Result:Inhibited tumor growth.
Chemical Information
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Masse moléculaire 692.31
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Formule C27H24Br2N4O8
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SMILES
COC([C@@H](NC(CN1C(C(C2=CC(Br)=CC=C21)=O)=O)=O)CCCCNC(CN3C(C(C4=CC(Br)=CC=C43)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-133 Related Classifications
HY-157548 Related Classifications
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