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Cat. No.: HY-157564

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Antitumor agent-135

Antitumor agent-135 (Compound 13) is a potent antitumor agent. Antitumor agent-135 induces cell apoptosis, with IC₅₀s of 3.79 , 10.55, 1.14, and 4.14 μM for NSCLC cell lines (A549, H460, PC-9, and PC-9/GR).

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CAS No.: 2922110-00-5
Formule: C₆₈H₇₇N₁₃O₁₆
Masse moléculaire:1332.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Antitumor agent-135 Chemical Structure

CAS No.: 2922110-00-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.79 μM Compound: 13	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38244939]
NCI-H460	IC₅₀	10.55 μM Compound: 13	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38244939]
PC-9	IC₅₀	1.14 μM Compound: 13	Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38244939]

Chemical Information

CAS No. 2922110-00-5
Masse moléculaire 1332.42
Formule C₆₈H₇₇N₁₃O₁₆
SMILES

[H][C@@]12C3=C(C4=CC(OC(N(CCN(C(OCC5=C(N(C6=C5C(C(OC)=CC6=O)=O)CC(NCCOCCOCCOCCN7C=C(N=N7)C8=CC(NC9=NC=NC%10=CC(OCCOC)=C(C=C%109)OCCOC)=CC=C8)=O)C)=O)C)C)=O)=CC=C4N3)CCN1C(C%11=CC=CC=C%11N2C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wei B, et al. Design, synthesis and bioactivity evaluation of the combination of evodiamine and erlotinib linked by indolequinone. Bioorg Med Chem Lett. 2024 Jan 18;99:129619. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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