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Cat. No.: HY-179442

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AR ligand-48

AR ligand-48 is an AR (Androgen Receptor) inhibitor and a ligand for the target protein for PROTAC (AR). AR ligand-48 can be used to synthesize PROTAC AR Degrader-12 (HY-179433).

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CAS No.: 1318208-88-6
Formule: C₂₃H₂₈N₂O₇
Masse moléculaire:444.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AR ligand-48 Chemical Structure

CAS No.: 1318208-88-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

AR ligand-48 is an AR (Androgen Receptor) inhibitor and a ligand for the target protein for PROTAC (AR). AR ligand-48 can be used to synthesize PROTAC AR Degrader-12 (HY-179433)^[1].

IC₅₀ & Target

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	40 nM Compound: 5	Inhibition of full length AR/PELP1 (unknown origin) interaction expressed in human LNCaP cells preincubated for 2 hrs followed by DHT addition measured after 24 hrs by Western blot analysis Inhibition of full length AR/PELP1 (unknown origin) interaction expressed in human LNCaP cells preincubated for 2 hrs followed by DHT addition measured after 24 hrs by Western blot analysis	[PMID: 27503683]

In Vitro

AR PROTAC contains two different ligands connected by a linker; one is an E3 ligase ligand ((S,S,S)-AHPC-Me) (Compound D2) (HY-112078), and the other is for Ligands of AR target protein (AR ligand-48) (HY-179442). PROTAC exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1318208-88-6
Masse moléculaire 444.48
Formule C₂₃H₂₈N₂O₇
SMILES

COC(C1=CC(OCC(C)C)=C(C=C1)NC(C2=CC(OCC(C)C)=C(C=C2)[N+]([O-])=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wu Y, et al. Kill Two Birds with One Stone: An Efficient and Potent AR CBS-Targeted Degrader Reverses Breast Cancer Resistance via Concurrent AR Degradation and ERα Transcriptional Suppression. J Med Chem. 2025 Nov 27;68(22):24136-24167. [Content Brief]

Calculators

Calculateur de molarité

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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