BAY 38-7271
BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist, with Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively. BAY 38-7271 has strong neuroprotective properties.
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- CAS No.: 212188-60-8
- Formule: C20H21F3O5S
- Masse moléculaire:430.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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CB1 1.85 nM (Ki) |
CB2 5.96 nM (Ki) |
BAY 38-7271 shows only minor interactions at the micromolar range with other binding sites such as adenosine A3 receptor (IC50 = 7.5 μM), peripheral GABAA benzodiazepine receptor (IC50 = 971 nM), melatonin ML1 receptor (IC50 = 3.3 μM), and at the monoamine transporter (IC50 = 1.7 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB1 receptor agonists[1].
BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model[1].
BAY 38-7271 also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rat ,TBI rat models (acute subdural hematoma, SDH)[1]
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Dosage:1 ng/kg/h, 10 ng/kg/h, 100 ng/kg/h, 1000 ng/kg/h
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Administration:Intravenous infusion, for 4 hours
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Result:Reduced the mean infarct volume.
Chemical Information
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CAS No. 212188-60-8
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Masse moléculaire 430.44
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Formule C20H21F3O5S
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SMILES
O=S(CCCC(F)(F)F)(OC1=CC=CC(OC2=CC=CC3=C2C[C@H](CO)C3)=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAY 38-7271 Related Classifications
HY-119744 Related Classifications
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