EBOV-IN-1
Based on 1 publication(s) in Google Scholar
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM.
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- Pureté: 98.66%
- CAS No.: 1335113-30-8
- Formule: C34H43N3O5
- Masse moléculaire:573.72
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) EBOV-IN-1
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
13 nM
Compound: 3.47
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Antiviral activity against VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs by fluorescence microsc
Antiviral activity against VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs by fluorescence microsc
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[PMID: 29920098] |
| Vero C1008 | IC50 |
64 nM
Compound: 3.47
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Antiviral activity against recombinant VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs in presence
Antiviral activity against recombinant VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs in presence
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[PMID: 29920098] |
Chemical Information
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CAS No. 1335113-30-8
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Appearance Solid
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Masse moléculaire 573.72
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Formule C34H43N3O5
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Color White to off-white
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SMILES
COC(=O)C1=CC=C(COC2=CC=CC=C2CN2CCN(C(=O)CNC(=O)CC34CC5CC(CC(C5)C3)C4)CC2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018-2020 epidemic. [Abstract]2026 Feb 5;189(3):818-831.e19. PMID: 41576953
Pureté et documentation
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Fiche technique (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EBOV-IN-1 Related Classifications
HY-W395779 Related Classifications
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