Galacto-PUGNAc
Galacto-PUGNAc is a selective competitive inhibitor of lysosomal β-hexosaminidases (HEX), with Ki values of 51 and 18 nM, for hHEXA and hHEXB, respectively. Galacto-PUGNAc elevates GM2 ganglioside levels in neuroblastoma cells. Galacto-PUGNAc can be used for the research of neurodegenerative disorders.
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- CAS No.: 1145878-98-3
- Formule: C15H19N3O7
- Masse moléculaire:353.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Galacto-PUGNAc inhibits purified G. gallus GH 27 α-N-acetylgalactosaminidase with a Ki of 140 mM, showing 2800-fold selectivity for human lysosomal β-hexosaminidases[1].
Galacto-PUGNAc (200 μM; 9 days) increases GM2 ganglioside levels by 30-40% in human SK-N-SH neuroblastoma cells[1].
Galacto-PUGNAc (50 μM; overnight) does not increase O-GlcNAc-modified protein levels in cultured human SK-N-SH neuroblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1145878-98-3
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Masse moléculaire 353.33
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Formule C15H19N3O7
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SMILES
O[C@@H]([C@@H](CO)O/1)[C@H](O)[C@@H](NC(C)=O)C1=N\OC(NC2=CC=CC=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Galacto-PUGNAc Related Classifications
HY-108241A Related Classifications
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