GalNAc-L96 free base
GalNAc-L96 free base is a conjugate of GalNAc and its ligand L96. When conjugated with the A-rich HCV sequence (H12), GalNAc-L96 free base binds potently to ASGPR, with a Ki value of 10.4 nM. GalNAc-L96 free base promotes siRNA delivery to hepatocytes.
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- CAS No.: 1159408-61-3
- Formule: C121H179N11O45
- Masse moléculaire:2507.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Humanized PCSK9 mice[1]
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Dosage:6 mg/kg
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Administration:s.c.; single dose
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Result:Reduced serum PCSK9 protein levels to ~10.2% of baseline at day 14 post-dose.
Reduced hepatic PCSK9 mRNA levels to ~19.9% of baseline at day 14 post-dose.
Chemical Information
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CAS No. 1159408-61-3
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Masse moléculaire 2507.76
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Formule C121H179N11O45
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SMILES
CC(N[C@H]([C@H]([C@H]([C@H](O1)COC(C)=O)OC(C)=O)OC(C)=O)[C@@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)NC(CCCCCCCCCCC(N(C[C@@H](C4)OC(CCC(O)=O)=O)[C@@H]4COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC)=O)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Pradeep SP, et al. Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates. Mol Ther Nucleic Acids. 2026;37(1):102871. Published 2026 Mar 4. [Content Brief]
[2]. Clua A, et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules. 2022;27(12):3944. Published 2022 Jun 20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GalNAc-L96 free base Related Classifications
HY-153184 Related Classifications
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