TIRAP - TIR domain containing adaptor protein Gene

Also Known as Mal; wyatt; BACTS1; MyD88-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114609

About TIRAP

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,283,093-126,294,933 (from NCBI)

This gene has 16 transcripts (splice variants), 188 orthologues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 2.7), ovary (RPKM 2.6) and 25 other tissues.

Summary

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

TIRAP Products (4)

mRNA	Protein	Name
NM_001039661.2	NP_001034750.1	toll/interleukin-1 receptor domain-containing adapter protein isoform a
NM_001318776.2	NP_001305705.1	toll/interleukin-1 receptor domain-containing adapter protein isoform b
NM_001318777.2	NP_001305706.1	toll/interleukin-1 receptor domain-containing adapter protein isoform a
NM_148910.3	NP_683708.1	toll/interleukin-1 receptor domain-containing adapter protein isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables Toll-like receptor 2 binding	IPI IPI: Inferred from physical interaction	19509286	GOA
enables Toll-like receptor 4 binding	IPI IPI: Inferred from physical interaction	19509286	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17258210	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11544529	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11544529	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	17161867	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	16751103	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	15294994	GOA
involved in TIRAP-dependent toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	11544529	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11544529	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	11544529	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of interleukin-15 production	IDA IDA: Inferred from direct assay	18583567	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16301656	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16301656	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	12062447	GOA
involved in positive regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16301656	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	11544529	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	16751103	GOA

Cellular Component GO Annotation	Evidence	Références	Source
is active in cell surface	IDA IDA: Inferred from direct assay	12447441	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19948740	GOA
is active in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	16751103	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	16751103	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19948740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIRAP Protein Structure

TIR_2

0
100
200
221 a.a.

Protein Preferred Names	Protein Names
toll/interleukin-1 receptor domain-containing adapter protein	MyD88 adapter-like protein

TIRAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TIRAP	P58753	LTN1	Homo sapiens	O94822	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	SAMHD1	Homo sapiens	Q9Y3Z3	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	33961781
Intra	TIRAP	P58753	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	ARAF	Homo sapiens	P10398	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	17583698
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Pull Down	17583698
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	11544529
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	21334391
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	33961781
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	MAPPIT	17258210
Intra	TIRAP	P58753	IRAK2	Homo sapiens	O43187	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	IRAK4	Homo sapiens	Q9NWZ3	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	TIRAP	Homo sapiens	P58753	X-Ray Diffraction	24275656
Intra	TIRAP	P58753	TLR4	Homo sapiens	O00206	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	TIRAP	Homo sapiens	P58753	MAPPIT	17258210
Intra	TIRAP	P58753	CCDC47	Homo sapiens	Q96A33	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	PIK3R1	Homo sapiens	P27986	IF	19574958

Cross: Cross-species interaction Intra: Intraspecies interaction

TIRAP Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82844	TIRAP Antibody (YA2589)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bacteremia 1	Bacteremia, Susceptibility To, 1 BACTS1 Bacteremia, Protection Against Bacteremia, Susceptibility To, Type 1
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Bacteriuria
Pelvic Inflammatory Disease	Pid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14551	TIRAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19486	Tirap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25980	Tirap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TIRAP	VGNC	VGNC:107652
Felis catus	TIRAP	VGNC	VGNC:104335
Rattus norvegicus	TIRAP	RGD	RGD:1595496
Bos taurus	TIRAP	VGNC	VGNC:35879
Mus musculus	TIRAP	MGD	MGI:2152213
Canis familiaris	TIRAP	VGNC	VGNC:47384
Others	TIRAP	NCBI