ANGPTL2 - angiopoietin like 2 Gene

Also Known as ARP2; HARP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23452

About ANGPTL2

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:127,087,348-127,122,635 (from NCBI)

This gene has 4 transcripts (splice variants), 128 orthologues and 25 paralogues. Broad expression in fat (RPKM 35.2), gall bladder (RPKM 19.9) and 22 other tissues.

Summary

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and Angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the Angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]

ANGPTL2 Products (1)

mRNA Protein Name
NM_012098.3 NP_036230.1 angiopoietin-related protein 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
22660330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPTL2 Protein Structure

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (276 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

angiopoietin-related protein 2

  • angiopoietin-like protein 2

ANGPTL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ANGPTL2 Q9UKU9 LILRB2 Homo sapiens Q8N423
FACS
24899623
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANGPTL2 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71652 ANGPTL2/Angiopoietin-like 2 Protein, Human (His-SUMO) Q9UKU9-1 (Q23-H493) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75577 ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His) Q9UKU9-1 (D245-H493) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78060 ANGPTL2/Angiopoietin-like 2 Protein, Human (Biotinylated, HEK293, His-Avi) Q9UKU9-1 (T260-H493) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78380 ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His-Avi) Q9UKU9-1 (T260-H493) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Myositis Ossificans

  • Myisitis Ossificans

  • Ossification - Muscle
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00691 ANGPTL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21226 Angptl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27742 Angptl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P992388 IO-108 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ANGPTL2 MGD MGI:1347002
Macaca mulatta ANGPTL2 VGNC VGNC:69814
Canis familiaris ANGPTL2 VGNC VGNC:37858
Bos taurus ANGPTL2 VGNC VGNC:25891
Rattus norvegicus ANGPTL2 RGD RGD:620004
Felis catus ANGPTL2 VGNC VGNC:67567
Others ANGPTL2 NCBI