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SHISA6 - shisa family member 6 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 388336

About SHISA6

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:11,241,213-11,564,063 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.7), endometrium (RPKM 2.0) and 9 other tissues.

Summary

Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; regulation of short-term neuronal synaptic plasticity; and regulation of signal transduction. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHISA6 Products (3)

mRNA	Protein	Name
NM_001173461.1	NP_001166932.1	protein shisa-6 isoform 2 precursor
NM_001173462.2	NP_001166933.1	protein shisa-6 isoform 3 precursor
NM_207386.4	NP_997269.2	protein shisa-6 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHISA6 Protein Structure

Shisa

0
100
200
300
400
500 a.a.

Protein Preferred Names	Protein Names
protein shisa-6	protein shisa-6 homolog

SHISA6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SHISA6	Q6ZSJ9	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	NEDD4	Homo sapiens	P46934-3	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	NEDD4	Homo sapiens	P46934-3	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	FBLIM1	Homo sapiens	Q8WUP2	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	FBLIM1	Homo sapiens	Q8WUP2	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	FBLIM1	Homo sapiens	Q8WUP2	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
Intra	SHISA6	Q6ZSJ9	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	SHISA6	Q6ZSJ9	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	SHISA6	Q6ZSJ9	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Scleral Staphyloma	Scleral Ectasia Staphyloma Of Sclera
Degenerative Myopia	Pathological Myopia Myopia, Degenerative Degenerative Progressive High Myopia Progressive High Myopia Progressive High Myopia
Griscelli Syndrome, Type 3	Griscelli Syndrome Type 3 GS3 Griscelli-Prunieras Syndrome Type 3 Hypomelanosis With No Immunologic Or Neurologic Manifestations Griscelli Syndrome 3
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked	Christ-Siemens-Touraine Syndrome XHED Ectodermal Dysplasia 1 Xlhed Ed1 Cst Syndrome Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked Ectd1 Ectodermal Dysplasia, Anhidrotic, X-Linked Eda Eda1 Hed1 Ectodermal Dysplasia 1, Anhidrotic X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia Hypohidrotic X-Linked Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, 1 Hypohidrotic Ectodermal Dysplasia, X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia X-Linked Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked Ectodermal Dysplasia Anhidrotic
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12869	SHISA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SHISA6	VGNC	VGNC:99449
Macaca mulatta	SHISA6	VGNC	VGNC:104650
Rattus norvegicus	SHISA6	RGD	RGD:1564618
Canis familiaris	SHISA6	VGNC	VGNC:46148
Mus musculus	SHISA6	MGD	MGI:2685725
Others	SHISA6	NCBI