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Adcy10 - adenylate cyclase 10 Gene

Also Known as Sac

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 59320

Summary

Enables ATPase binding activity; Adenylate Cyclase activity; and manganese ion binding activity. Involved in cAMP biosynthetic process and positive regulation of apoptotic process. Located in several cellular components, including basal part of cell; growth cone; and neuronal cell body. Orthologous to human ADCY10 (Adenylate Cyclase 10). [provided by Alliance of Genome Resources, Apr 2022]

Adcy10 Products (1)

mRNA	Protein	Name
NM_021684.1	NP_067716.1	adenylate cyclase type 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	17959750	RGD
enables adenylate cyclase activity	IDA IDA: Inferred from direct assay	7225326	RGD
enables manganese ion binding	IDA IDA: Inferred from direct assay	7225326	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in cAMP biosynthetic process	IDA IDA: Inferred from direct assay	7225326	RGD
involved in cAMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	16627466	RGD
involved in glucose catabolic process	IMP IMP: Inferred from mutant phenotype	22998876	RGD
involved in mitochondrial ATP transmembrane transport	IMP IMP: Inferred from mutant phenotype	32664470	RGD
involved in negative regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	31754830	RGD
involved in negative regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	28386847	RGD
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	32664470	RGD
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	25009261	RGD
involved in neuron projection maintenance	IMP IMP: Inferred from mutant phenotype	22649251	RGD
involved in neuron projection retraction	IMP IMP: Inferred from mutant phenotype	22649251	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	31172217	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19336406	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	22649251	RGD
involved in positive regulation of cAMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	31172217	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22106416	RGD
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	29466442	RGD
involved in positive regulation of glycogen catabolic process	IMP IMP: Inferred from mutant phenotype	22998876	RGD
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	23729662	RGD
involved in positive regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	31172217	RGD
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	30067871	RGD
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	28386847	RGD
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	22106416	RGD
involved in positive regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	22106416	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	28386847	RGD
involved in positive regulation of vascular associated smooth muscle cell apoptotic process	IDA IDA: Inferred from direct assay	23729662	RGD
involved in regulation of membrane repolarization	IMP IMP: Inferred from mutant phenotype	32664470	RGD
involved in regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	31172217	RGD
involved in spermatid development	IEP IEP: Inferred from expression pattern	14697363	RGD

Cellular Component GO Annotation	Evidence	Références	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	17959750	RGD
located in astrocyte end-foot	IDA IDA: Inferred from direct assay	22998876	RGD
located in axon	IDA IDA: Inferred from direct assay	16964251	RGD
located in basal part of cell	IDA IDA: Inferred from direct assay	17959750	RGD
located in central region of growth cone	IDA IDA: Inferred from direct assay	22649251	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	22649251	RGD
located in cytosol	IDA IDA: Inferred from direct assay	31754830	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16964251	RGD
located in growth cone	IDA IDA: Inferred from direct assay	16964251	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	22106416	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16964251	RGD
located in nucleus	IDA IDA: Inferred from direct assay	22649251	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
adenylate cyclase type 10	adenylate cyclase 10 (soluble) germ cell soluble adenylyl cyclase soluble adenylyl cyclase testicular soluble adenylyl cyclase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-132298	TDI-10229	Inhibitor	99.00%	Unkown
HY-151798	TDI-11861	Inhibitor	99.35%	Unkown
HY-RS00327	ADCY10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18004	Adcy10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24476	Adcy10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcy10	NCBI	NCBI:55811