RPL11 - ribosomal protein L11 Gene

Also Known as L11; uL5; DBA7; GIG34

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6135

About RPL11

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,691,779-23,696,835 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 1447.2), bone marrow (RPKM 910.3) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

RPL11 Products (2)

mRNA	Protein	Name
NM_000975.5	NP_000966.2	60S ribosomal protein L11 isoform 1
NM_001199802.1	NP_001186731.1	60S ribosomal protein L11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables 5S rRNA binding	IMP IMP: Inferred from mutant phenotype	18560357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15195100	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	18697920	GOA
enables ubiquitin ligase inhibitor activity	IMP IMP: Inferred from mutant phenotype	18560357	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18560357	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA
involved in negative regulation of protein neddylation	IDA IDA: Inferred from direct assay	18560357	GOA
involved in negative regulation of ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	18560357	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	18560357	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18560357	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	18560357	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	18560357	GOA
involved in protein targeting	IMP IMP: Inferred from mutant phenotype	15195100	GOA
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit assembly	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15314173	GOA
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	25957688	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	15195100	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	23776465	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15314173	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL11 Protein Structure

Ribosomal_L5

Ribosomal_L5_C

0
100
178 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L11	CLL-associated antigen KW-12

RPL11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RPL11	P62913	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	RPL11	P62913	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	RPL11	P62913	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	RPL11	P62913	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	RPL11	P62913	CAMK2B	Homo sapiens	Q13554	Y2H Array	25416956
Intra	RPL11	P62913	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25910212
Intra	RPL11	P62913	RPL10A	Homo sapiens	P62906	Anti Tag CoIP	33961781
Intra	RPL11	P62913	RPL10A	Homo sapiens	P62906	Anti Tag CoIP	35271311
Intra	RPL11	P62913	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	23507139
Intra	RPL11	P62913	MDM2	Homo sapiens	Q00987	Y2H Array	21988832
Intra	RPL11	P62913	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	17110929
Intra	RPL11	P62913	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	33961781
Intra	RPL11	P62913	MDM2	Homo sapiens	Q00987	Y2H	17310983
Intra	RPL11	P62913	NEDD8	Homo sapiens	Q15843	Pull Down	19713960

Cross: Cross-species interaction Intra: Intraspecies interaction

RPL11 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P810916	RPL11 Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 7	DBA7 Rpl11-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 7
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Diamond-Blackfan Anemia 1	Aase Syndrome DBA1 Erythrogenesis Imperfecta Aase-Smith Syndrome Ii Dba Blackfan-Diamond Syndrome Bds Anemia, Congenital Hypoplastic, Of Blackfan And Diamond Anemia, Congenital Erythroid Hypoplastic Red Cell Aplasia, Pure, Hereditary Aregenerative Anemia, Chronic Congenital Rps19-Related Diamond-Blackfan Anemia Chronic Congenital Aregenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Pure Hereditary Red Cell Aplasia Anemia, Diamond-Blackfan, Type 1 Anemia, Diamond-Blackfan Aase Smith Syndrome 2 Familial Hypoplastic Anaemia With Malformations Constitutional Pure Red Cell Aplasia
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Macrocytic Anemia	Anemia Macrocytic Anemia, Macrocytic Macrocytic Anaemia
Pierre Robin Syndrome	Pierre Robin Sequence Glossoptosis, Micrognathia, And Cleft Palate Pierre Robin Syndrome Skeletal Dysplasia Polydactyly Pierre-Robin Syndrome Isolated Pierre Robin Sequence Isolated Pierre-Robin Syndrome PRBNS Robin Sequence Robin Syndrome Isolated Pierre Robin Syndrome
Acrofacial Dysostosis, Cincinnati Type	Acrofacial Dysostosis Cincinnati Type AFDCIN Dysostosis, Acrofacial, Cincinnati Type
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Pure Red-Cell Aplasia	Pure Red Cell Aplasia Primary Red Cell Aplasia Red Cell Hypoplasia Prca Red-Cell Aplasia Pure Red-Cell Aplasia, Pure
Bowen-Conradi Syndrome	BWCNS Bowen Hutterite Syndrome Bowen-Conradi Hutterite Syndrome Bowen Syndrome, Hutterite Type Bowen Hutterite Syndrome, Formerly Hutterite Syndrome Bowen Syndrome Hutterite Type Fetal Growth Retardation
Dyskeratosis Congenita, X-Linked	DKCX X-Linked Dyskeratosis Congenita Zinsser-Cole-Engman Syndrome Hoyeraal-Hreidarsson Syndrome Dyskeratosis Congenita X-Linked HHS Cerebellar Hypoplasia With Pancytopenia Prenatal Growth Retardation With Progressive Pancytopenia And Cerebellar Hypoplasia Dyskeratosis Congenita
Treacher Collins Syndrome 1	Treacher Collins Syndrome Mandibulofacial Dysostosis Treacher Collins-Franceschetti Syndrome Tcof Tcs Mfd1 Franceschetti-Klein Syndrome TCS1 Franceschetti Syndrome Franceschetti-Zwahlen-Klein Syndrome Zygoauromandibular Dysplasia Treacher-Collins Syndrome Mandibulofacial Dysostosis Without Limb Anomalies Bilateral And Symmetric Oto-Mandibular Dysplasia
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Orofacial Cleft	Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12162	RPL11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL11	RGD	RGD:1308681
Canis familiaris	RPL11	VGNC	VGNC:54771
Macaca mulatta	RPL11	VGNC	VGNC:76922
Bos taurus	RPL11	VGNC	VGNC:34108
Mus musculus	RPL11	MGD	MGI:1914275
Others	RPL11	NCBI