Hecogenin
Based on 1 publication(s) in Google Scholar
Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.
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- Pureté: 99.96%
- CAS No.: 467-55-0
- Formule: C27H42O4
- Masse moléculaire:430.62
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hecogenin
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Activité biologique
Human UDP-glucuronosyltransferases[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>40 μM
Compound: Hecogenin
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 33735799] |
| BT-474 | IC50 |
38.2 μM
Compound: 1
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Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
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[PMID: 29066046] |
| HT-29 | IC50 |
>40 μM
Compound: Hecogenin
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Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 33735799] |
| HUVEC | IC50 |
>100 μM
Compound: Hecogenin
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Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 33735799] |
| MCF7 | IC50 |
28.7 μM
Compound: Hecogenin
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 33735799] |
| MCF7 | IC50 |
31 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 29066046] |
| MDA-MB-231 | IC50 |
28.7 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
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[PMID: 29066046] |
| MDA-MB-231 | IC50 |
31.21 μM
Compound: Hecogenin
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 33735799] |
| MDA-MB-231 | IC50 |
37.1 μM
Compound: 1
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Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
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[PMID: 29066046] |
| MDA-MB-468 | IC50 |
35.2 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
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[PMID: 29066046] |
| SK-BR-3 | IC50 |
33.3 μM
Compound: 1
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Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
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[PMID: 29066046] |
| T47D | IC50 |
36.6 μM
Compound: 1
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Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
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[PMID: 29066046] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss mice (20-30 g) with ethanol[1]
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Dosage:3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
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Administration:Oral administration; for 15 hours
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Result:Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
Chemical Information
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CAS No. 467-55-0
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Appearance Solid
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Masse moléculaire 430.62
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Formule C27H42O4
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Color White to off-white
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SMILES
[H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@@H](C)[C@@]1([C@]34C)[H])C[C@@]3([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC4=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Curr Issues Mol Biol
Cinnamomum migao H.W. Li Ethanol-Water Extract Suppresses IL-6 Production in Cardiac Fibroblasts: Mechanisms Elucidated via UPLC-Q-TOF-MS, Network Pharmacology, and Experimental Assays. [Abstract]2025 Sep 26;47(10):798. PMID: 41150746
Solvant et solubilité
DMF : 16.67 mg/mL (38.71 mM; ultrasonic and warming and heat to 60°C)
H2O : < 0.1 mg/mL (insoluble)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.3222 mL | 11.6112 mL | 23.2223 mL | 58.0558 mL |
| 5 mM | 0.4644 mL | 2.3222 mL | 4.6445 mL | 11.6112 mL | |
| 10 mM | 0.2322 mL | 1.1611 mL | 2.3222 mL | 5.8056 mL | |
| 15 mM | 0.1548 mL | 0.7741 mL | 1.5482 mL | 3.8704 mL | |
| 20 mM | 0.1161 mL | 0.5806 mL | 1.1611 mL | 2.9028 mL | |
| 25 mM | 0.0929 mL | 0.4644 mL | 0.9289 mL | 2.3222 mL | |
| 30 mM | 0.0774 mL | 0.3870 mL | 0.7741 mL | 1.9352 mL |
Hecogenin Related Classifications
HY-N1422 Related Classifications
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