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Cat. No.: HY-N3401

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Lasiodiplodin

Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens.

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CAS No.: 32885-81-7

Formule: C₁₇H₂₄O₄

Masse moléculaire:292.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Lasiodiplodin Chemical Structure

CAS No.: 32885-81-7

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Data Download

Data Sheet (267 KB)

Instruction de manipulation (2659 KB)

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Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec

Activité biologique

Chemical Information

Pureté et documentation

Références

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

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Help & FAQs

Classifications

Bioz

Activité biologique

Description

Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens^[1].

Cellular Effect

Cell Line

Type Value Description References

BV-2 IC₅₀
>100 μM
Compound: 10

Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay

Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay
[PMID: 27592135]

U-937 IC₅₀
20 μM
Compound: 32, lasiodiplodin

Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay

Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
[PMID: 17158054]

U-937 IC₅₀
28 μM
Compound: 32, lasiodiplodin

Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay

Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
[PMID: 17158054]

U-937 IC₅₀
36 μM
Compound: 32, lasiodiplodin

Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay

Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
[PMID: 17158054]

Chemical Information

CAS No. 32885-81-7

Masse moléculaire 292.37

Formule C₁₇H₂₄O₄

SMILES

COC1=C2C(CCCCCCC[C@@H](OC2=O)C)=CC(O)=C1

Structure Classification

Others

Initial Source

Microorganisms

endophytic fungus

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Leet K H, et al. Lasiodiplodin, a potent antileukemic macrolide from Euphorbia splendens[J]. Phytochemistry, 1982, 21(5): 1119-1121.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Lasiodiplodin Related Classifications

HY-N3401 Related Classifications

Aires thérapeutique

Cancer

Produits naturels

Microorganisms Others

Étalons de référence

Natural Product Standards

Others

Cancer

Cancer Metabolism and Metastasis

Powered by Bioz See more details on Bioz

Keywords

Lasiodiplodin
32885-81-7
Others
anti-leukemic
Inhibitor
inhibitor
inhibit

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Cell Line	Type	Value	Description	References
BV-2	IC₅₀	>100 μM Compound: 10	Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay	[PMID: 27592135]
U-937	IC₅₀	20 μM Compound: 32, lasiodiplodin	Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay	[PMID: 17158054]
U-937	IC₅₀	28 μM Compound: 32, lasiodiplodin	Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay	[PMID: 17158054]
U-937	IC₅₀	36 μM Compound: 32, lasiodiplodin	Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay	[PMID: 17158054]

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