NAMPT activator-9
NAMPT activator-9 (Compound DIPM) is an allosteric, non-competitive NAMPT activator, with an EC50 of 3.366 μM against hNAMPT. NAMPT activator-9 enhances the enzymatic activity of NAMPT via an allosteric, non-competitive mechanism. NAMPT activator-9 increases intracellular NAD+ levels. NAMPT activator-9 restores myotube diameter and reduces the expression of atrophy markers Atrogin-1 and MuRF1. NAMPT activator-9 is applicable to research related to muscle atrophy.
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- CAS No.: 931366-46-0
- Formule: C17H15N5O
- Masse moléculaire:305.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
NAMPT activator-9 (60 min) is a potent allosteric activator of hNAMPT, with an EC50 of 3.366 μM[1].
NAMPT activator-9 (0.741-20 μM; 24 h) significantly increases the intracellular NAD+ level and NAD+/NADH ratio in fully differentiated C2C12 myotubes; after treatment with 2.222 μM for 24 h, the NAD+ level increases by approximately 2-fold[1].
NAMPT activator-9 (2.222-20 μM; 24 h) protects fully differentiated C2C12 myotubes against Dexamethasone (HY-14648)-induced atrophy by reducing the expression of atrophy markers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Fully differentiated C2C12 myotubes
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Concentration:0.247-4860 μM
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Incubation Time:24 h
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Result:Showed no obvious toxicity in C2C12 myotubes up to 180 μM, with an IC50 value of 1.98 mM.
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Cell Line:Fully differentiated C2C12 myotubes (dexamethasone-induced atrophy model)
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Concentration:2.222-20 μM (co-incubated with 10 μM dexamethasone)
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Incubation Time:24 h
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Result:Nearly completely abolished Dexamethasone-induced upregulation of Atrogin-1 and MuRF1 expression.
Reversed dexamethasone-induced reduction of MyHC expression, with significant recovery at all tested concentrations.
Chemical Information
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CAS No. 931366-46-0
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Masse moléculaire 305.33
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Formule C17H15N5O
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SMILES
O=C(N1CC2=C(C=CC=C2)CC1)C3=CC=C(C4=NNN=N4)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NAMPT activator-9 Related Classifications
HY-182062 Related Classifications
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