NFATc1-IN-1
Based on 4 publication(s) in Google Scholar
NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research.
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- Pureté: 99.97%
- CAS No.: 1912422-56-0
- Formule: C13H8F2INO2
- Masse moléculaire:375.11
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NFATc1-IN-1
More
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | CC50 |
7.4 μM
Compound: A04
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 27089213] |
| RAW264.7 | IC50 |
1.57 μM
Compound: A04
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Inhibition of RANKL-induced osteoclast differentiation in mouse RAW264.7 cells assessed as reduction in TRAP-positive multinucleated cells level incubated with compound in presence of RANKL for 4 days by TRAP staining based light microscopic analysis rela
Inhibition of RANKL-induced osteoclast differentiation in mouse RAW264.7 cells assessed as reduction in TRAP-positive multinucleated cells level incubated with compound in presence of RANKL for 4 days by TRAP staining based light microscopic analysis rela
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[PMID: 27089213] |
NFATc1-IN-1 (compound A04) (0-2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption[1].
NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Osteoclast precursor RAW 264.7 cells
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Concentration:0, 0.5, 1.0, 1.5, 2.0 and 2.5 μM
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Incubation Time:4 days
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Result:Markedly reduced the number and size of red TRAP-positive multinucleated osteoclasts at concentrations of 1.5, 2.0, and 2.5 μM. Significantly inhibited formation of osteoclasts in a dose-dependent manner (at 1.5, 2.0 and 2.5 μM), while showing no cytotoxic effects towards osteoclast precursor cells at concentrations of as high as 2.5 μM.
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Cell Line:RAW264.7 cells
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Concentration:1.5 or 2.5 μM
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Incubation Time:24 h
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Result:Blocked NFATc1 nuclear translocation and decreased the level of NFATc1.
Chemical Information
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CAS No. 1912422-56-0
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Appearance Solid
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Masse moléculaire 375.11
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Formule C13H8F2INO2
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Color White to off-white
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SMILES
OC1=C(C(NC2=C(F)C=C(I)C=C2)=O)C=C(F)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Inflamm Res
2023 Jun;72(6):1237-1255. PMID: 37212865 -
Oncogenesis
NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression. [Abstract]2025 Nov 7;14(1):39. PMID: 41203626 -
Tissue Cell
2026 Apr:99:103263. PMID: 41365188 -
Tissue Cell
The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption. [Abstract]2025 Feb:92:102643. PMID: 39612595
Solvant et solubilité
DMSO : 125 mg/mL (333.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6659 mL | 13.3294 mL | 26.6588 mL | 66.6471 mL |
| 5 mM | 0.5332 mL | 2.6659 mL | 5.3318 mL | 13.3294 mL | |
| 10 mM | 0.2666 mL | 1.3329 mL | 2.6659 mL | 6.6647 mL | |
| 15 mM | 0.1777 mL | 0.8886 mL | 1.7773 mL | 4.4431 mL | |
| 20 mM | 0.1333 mL | 0.6665 mL | 1.3329 mL | 3.3324 mL | |
| 25 mM | 0.1066 mL | 0.5332 mL | 1.0664 mL | 2.6659 mL | |
| 30 mM | 0.0889 mL | 0.4443 mL | 0.8886 mL | 2.2216 mL | |
| 40 mM | 0.0666 mL | 0.3332 mL | 0.6665 mL | 1.6662 mL | |
| 50 mM | 0.0533 mL | 0.2666 mL | 0.5332 mL | 1.3329 mL | |
| 60 mM | 0.0444 mL | 0.2222 mL | 0.4443 mL | 1.1108 mL | |
| 80 mM | 0.0333 mL | 0.1666 mL | 0.3332 mL | 0.8331 mL | |
| 100 mM | 0.0267 mL | 0.1333 mL | 0.2666 mL | 0.6665 mL |
NFATc1-IN-1 Related Classifications
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