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Cat. No.: HY-180480

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NSC 104999

NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (K_d = 32.3 μM). NSC 104999 exhibits anticancer activity against breast cancer.

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CAS No.: 1118745-14-4
Formule: C₃₆H₄₂N₈O₄
Masse moléculaire:650.77

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC 104999 Chemical Structure

CAS No.: 1118745-14-4

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
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Activité biologique

Description

NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (K_d = 32.3 μM). NSC 104999 exhibits anticancer activity against breast cancer^[1].

IC₅₀ & Target

K_d = 32.3 μM (Grb7 SH2 domain)^[1]

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Chemical Information

CAS No. 1118745-14-4
Masse moléculaire 650.77
Formule C₃₆H₄₂N₈O₄
SMILES

O=C(C1=CC=C(C(NC2=CC(C3=NCCN3)=CC(C(NCCCC)=O)=C2)=O)C=C1)NC4=CC(C5=NCCN5)=CC(C(NCCCC)=O)=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ambaye ND, et al. The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents. ChemMedChem. 2013 Feb;8(2):280-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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NSC 104999

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NSC 104999 Related Classifications

HY-180480 Related Classifications