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Cat. No.: HY-182617

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NSC-13030

NSC-13030 is a SHP2 inhibitor with an IC₅₀ value of 3.2 μM. NSC-13030 reduces the proliferation and viability of breast cancer cells. NSC-13030 is applicable to breast cancer-related research.

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CAS No.: 5442-51-3
Formule: C₁₈H₁₄ClNO₅S
Masse moléculaire:391.83

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC-13030 Chemical Structure

CAS No.: 5442-51-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

NSC-13030 (100 μM; 5 min pre-incubation, 90 min substrate incubation) potently and selectively inhibits purified SHP2 protein with an IC₅₀ of 3.2 μM, and shows weak inhibition of purified SHP1 protein with an IC₅₀ of 85.4 μM^[1].
NSC-13030 (0.16-20 μM; 48 h) dose-dependently reduces the proliferation and viability of MCF-7 breast cancer cells, with a 42.1% reduction in proliferation and 64.4% reduction in viability at 20 μM after 48 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7 estrogen-positive breast cancer cells
Concentration:

0.16, 0.8, 4, and 20 μM
Incubation Time:

48 h
Result:

Reduced MCF-7 cell proliferation and viability in a dose-dependent manner.
Reduced MCF-7 cell proliferation by 42.1% at 20 μM compared to DMSO vehicle control.
Reduced MCF-7 cell viability by 64.4% at 20 μM compared to DMSO vehicle control.

Chemical Information

CAS No. 5442-51-3
Masse moléculaire 391.83
Formule C₁₈H₁₄ClNO₅S
SMILES

O=C(CC(C(O)=O)SC1=C2C=CC(Cl)=CC2=NC3=C1C=C(OC)C=C3)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ghemrawi R, et al. The Discovery of Potent SHP2 Inhibitors with Anti-Proliferative Activity in Breast Cancer Cell Lines. Int J Mol Sci. 2022;23(8):4468. Published 2022 Apr 18. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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