P-gp-IN-35
P-gp-IN-35 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-35 exhibits cytotoxicity against sensitive breast cancer and colorectal cancer cells, and can reverse multidrug resistance in breast cancer cells with P-gp overexpression. P-gp-IN-35 can be used in research related to multidrug-resistant breast cancer and colon cancer.
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- CAS No.: 1887151-21-4
- Formule: C20H13ClN2O3
- Masse moléculaire:364.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
P-gp-IN-35 (Compound 4d) (24 h) potently inhibits the proliferation of MCF-7, Caco-2 and multidrug-resistant MCF-7/ADR cancer cells with IC50 values of 8.14, 9.04 and 19.32 μM, respectively; compared with normal HFL-1 and WI-38 lung fibroblasts, this compound exhibits selective toxicity toward cancer cells[1].
P-gp-IN-35 (1-100 μM; 48 h) downregulates the expression of P-glycoprotein in MCF-7/ADR cells in a concentration-dependent manner, with an inhibition rate of 61.27% at 100 μM. It also reverses P-gp-mediated multidrug resistance, with an IC50 of 15.09 μM[1].
P-gp-IN-35 inhibits the activity of P-glycoprotein efflux pump in MCF-7/ADR cells, with an IC50 value of 47.08 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7/ADR
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Concentration:1 μM, 10 μM, 100 μM
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Incubation Time:48 h
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Result:Reduced P-gp expression by 17.55% at 1 μM.\nReduced P-gp expression by 35.6% at 10 μM.\n
Reduced P-gp expression by 61.27% at 100 μM.\n
Inhibited P-gp-mediated multidrug resistance in MCF-7/ADR cells with an IC50 of 15.09 μM.
Chemical Information
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CAS No. 1887151-21-4
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Masse moléculaire 364.78
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Formule C20H13ClN2O3
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SMILES
NC(O1)=C(C#N)C(C2=CC=CC(Cl)=C2)C3=C1C4=CC(C)=CC=C4OC3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P-gp-IN-35 Related Classifications
HY-181252 Related Classifications
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