Pasotuxizumab
Based on 1 publication(s) in Google Scholar
Pasotuxizumab (BAY 2010112) is a PSMA and CD3 bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with KDs of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC).
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- Pureté: 99.79%
- CAS No.: 1442657-12-6
- Masse moléculaire:53.55 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pasotuxizumab
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Activité biologique
(scFv-heavy-kappa)-(scFv-heavy-lambda)
Human
CD3E & FOLH1
Pasotuxizumab (0-100 ng/mL approximately, 48 h) leads to activation of CD4+ and CD8+ T cell populations, with EC50s of 3.4-6.7 ng/mL for human cocultures, and 13.7-21.2 ng/mL for cynomolgus monkey cell cocultures[2].
Pasotuxizumab (0-100 ng/mL approximately, 48 h) increases release of interferon-γ, TNF-α, IL-2 and IL-10 in T cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pasotuxizumab (0-100 ng/mL approximately, 48 h) increases release of interferon-γ, TNF-α, IL-2 and IL-10 in T cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PC-3-huPSMA mouse xenograft model[2]
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Dosage:0.005-5 mg/kg
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Administration:i.v., once daily
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Result:Inhibited tumor growth by 86% (0.005 mg/kg/d) and 99% (5 mg/kg/d).
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Animal Model:BALB/c mice (PK Assay)[2]
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Dosage:0.1, 0.3, and 1 mg/kg
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Administration:i.v. bolus administration or s.c.
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Result:Pharmacokinetic profile of Rafivirumab.
Dose (mg/kg) AUC (mg h/L) CLmatrix (L/h/kg) T1/2 (h) F (%) i.v. (0.3) 0.93 0.32 9.7 100 s.c. (0.3) 0.17 11 18
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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(scFv-heavy-kappa)-(scFv-heavy-lambda)
-(scFv-heavy-lambda).png)
ELISA, FACS, Functional assay
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Immobilized PSMA Protein, Human (HEK293, His, HY-P70548A) can bind Pasotuxizumab. The EC50 for this effect is 315.4 ng/mL. -
Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, His, HY-P72726) can bind Pasotuxizumab. The EC50 for this effect is 6.564 ng/mL.
Chemical Information
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CAS No. 1442657-12-6
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Appearance Liquid
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Masse moléculaire 53.55 kDa
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Color Colorless to light yellow
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SMILES
[Pasotuxizumab]
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Synonyms
BAY 2010112; AMG 212; MT112
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
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Fiche technique (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pasotuxizumab Related Classifications
HY-P99802 Related Classifications
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