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Cat. No.: HY-183198

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PIM-IN-5

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2139294-71-4
Formule: C₁₆H₁₈Cl₂N₄O
Masse moléculaire:353.25

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIM-IN-5 Chemical Structure

CAS No.: 2139294-71-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia^[1].

Voir tous les produits spécifiques à Isoform Pim :

Cellular Effect

Cell Line	Type	Value	Description	References
KG-1	IC₅₀	62 nM Compound: (S)-11	Antiproliferative activity against human KG1 cells Antiproliferative activity against human KG1 cells	[PMID: 28927793]

In Vitro

PIM-IN-5 (Compound 1) inhibits KG1 cell viability with an EC₅₀ of 43 nM^[1].
PIM-IN-5 inhibits pS6 in KG1 cells with an EC₅₀ of 62 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2139294-71-4
Masse moléculaire 353.25
Formule C₁₆H₁₈Cl₂N₄O
SMILES

ClC1=C(C2CC2)N([C@H]3CCCNC3)C4=NC(C(N)=O)=CC(Cl)=C41
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Barberis C, et al. Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III. Bioorg Med Chem Lett. 2019;29(3):491-495. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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PIM-IN-5

Voir tous les produits spécifiques à Isoform Pim

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PIM-IN-5 Related Classifications

HY-183198 Related Classifications