Tirzepatide improves neutrophilic inflammation in obese asthmatic mice by downregulating Th17 cell differentiation

  • Mol Biol Rep. 2025 Dec 13;53(1):197. doi: 10.1007/s11033-025-11366-6.
Lu Sun  #  1 ,  Su-Yan Yao  #  2 ,  Zhong-Fu Zuo  3  4 ,  Sheng-Xue Yu  3  4 ,  Hong-Dan Yu  3  4 ,  Qing-Lin Sun  5 ,  Han-Song Zheng  6 ,  Yang Hou  3 ,  Si-Jing Lu  7 ,  Tie-Feng Yao  8  9
Affiliations
  • 1. Department of Pathology, Jinzhou Medical University, Jinzhou, China.
  • 2. Department of pathophysiology, Jinzhou Medical University, Jinzhou, China.
  • 3. Department of Anatomy, Histology and Embryology, Jinzhou Medical University, Jinzhou, China.
  • 4. Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou, China.
  • 5. Department of Third Clinical College, Jinzhou Medical University, Jinzhou, China.
  • 6. Department of First Clinical College, Tianjin Medical University, Tianjin, China.
  • 7. The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China. [email protected].
  • 8. Department of Anatomy, Histology and Embryology, Jinzhou Medical University, Jinzhou, China. [email protected].
  • 9. Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou, China. [email protected].
  • # Contributed equally.
PMID: 41389087 DOI: 10.1007/s11033-025-11366-6
Keywords
Obesity-related asthma · Th17 · Tirzepatide · NOTCH · Neutrophil.
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