Relcobatinib
Relcobatinib (Relcobatinibum) is a ABL1 kinase inhibitor with an IC50 of 12.7 nM against wild-type ABL1 and an IC50 of 43.5 nM against the ABL1T315I mutant. Relcobatinib inhibits the phosphorylation of CRKL. Relcobatinib exhibits anticancer activity against chronic myeloid leukemia. Relcobatinib can be used in studies related to chronic myeloid leukemia.
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- CAS No.: 2767305-95-1
- Formule: C18H12D6FN5O3
- Masse moléculaire:377.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Abl1 12.7 nM (IC50) |
Abl1T315I 43.5 nM (IC50) |
Relcobatinib (Compound 95) potently inhibits K562 cell proliferation with an IC50 of 47.8 nM and weakly inhibits HL60 cell proliferation with an IC50 of 3550 nM[1].
Relcobatinib inhibits wild-type ABL1 kinase activity with an IC50 of 12.7 nM and ABL1T315I mutant kinase activity with an IC50 of 43.5 nM in a cell-free biochemical assay[1].
Relcobatinib inhibits CRKL phosphorylation in K562 cells with an IC50 of 66.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2767305-95-1
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Unlabeled Cas 2767304-26-5
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Masse moléculaire 377.40
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Formule C18H12D6FN5O3
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SMILES
CN1C(C2=C(OC([2H])([2H])[2H])N=CN=C2OC([2H])([2H])[2H])=CC3=CC(NC([C@H]4[C@H](C4)F)=O)=NC=C31
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Synonyms
Relcobatinibum
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Relcobatinib Related Classifications
HY-184100S Related Classifications
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