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Safimestomig

(Synonyms: 6MW3211)
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Based on 1 Customer Validation

Safimestomig (6MW3211) is an CD47/PD-L1-targeting bispecific antibody. Safimestomig blocks CD47-mediated 'don't eat me' signaling and selectively binds to CD47 on tumor cells. Safimestomig blocks PD-L1-mediated immune checkpoint signaling. Safimestomig can be used for the research of cancer.

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  • Pureté: ≥99.0%
  • CAS No.: 2911590-72-0
  • Masse moléculaire:145.515 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Safimestomig
  • Experimental Validation Results for Safimestomig
  • Experimental Validation Results for Safimestomig
  • Experimental Validation Results for Safimestomig
  • Safimestomig Chemical Structure
    Safimestomig Chemical Structure
CAS No.: 2911590-72-0
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Safimestomig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG4-kappa

  • 1/16

    Immobilized CD47 Protein, Human (HEK293, HY-P72917) can bind Safimestomig. The EC50 for this effect is 781.3 ng/mL.

  • 1/16

    Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Safimestomig. The EC50 for this effect is 14.82 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Juakat cells with Safimestomig (HY-P991023, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Safimestomig Chemical Structure
    1/16
  • Safimestomig
  • Immobilized CD47 Protein, Human (HEK293, HY-P72917) can bind Safimestomig. The EC50 for this effect is 781.3 ng/mL.
  • Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Safimestomig. The EC50 for this effect is 14.82 ng/mL.
  • Flow cytometric analysis of 1X106 Juakat cells with Safimestomig (HY-P991023, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG4-kappa