Cat. No.: HY-117429

Se-Aspirin

(Synonyms: Selenium-acetylsalicylic acid)

Se-Aspirin is a hybrid molecule of selenium and Aspirin (HY-14654). Se-Aspirin reduces the viability of cancer cell lines, particularly colorectal cancer cells.

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CAS No.: 1850293-95-6
Formule: C₁₂H₁₂N₂O₃Se
Masse moléculaire:311.20

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Se-Aspirin Chemical Structure

CAS No.: 1850293-95-6

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Se-Aspirin is a hybrid molecule of selenium and Aspirin (HY-14654). Se-Aspirin reduces the viability of cancer cell lines, particularly colorectal cancer cells^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	2.9 μM Compound: 8	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
DU-145	IC₅₀	3.4 μM Compound: 8	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
DU-145	IC₅₀	8.2 μM Compound: 8	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
HCT-116	IC₅₀	16.2 μM Compound: 8	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
HCT-116	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
HCT-116	IC₅₀	2.5 μM Compound: 8	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
HepG2	IC₅₀	16 μM Compound: 8	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
HepG2	IC₅₀	4.3 μM Compound: 8	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
HepG2	IC₅₀	5 μM Compound: 8	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
HT-29	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
HT-29	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
HT-29	IC₅₀	3.4 μM Compound: 8	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
MDA-MB-231	IC₅₀	21.1 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
MDA-MB-231	IC₅₀	5.5 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
MDA-MB-231	IC₅₀	6 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
NCI-H460	IC₅₀	>50 μM Compound: 8	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
NCI-H460	IC₅₀	1.3 μM Compound: 8	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
NCI-H460	IC₅₀	2.4 μM Compound: 8	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
PANC-1	IC₅₀	12.1 μM Compound: 8	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
PANC-1	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
PANC-1	IC₅₀	2.6 μM Compound: 8	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
RKO	IC₅₀	13.3 μM Compound: 8	Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
RKO	IC₅₀	2.2 μM Compound: 8	Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
RKO	IC₅₀	2.9 μM Compound: 8	Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
SK-OV-3	IC₅₀	>50 μM Compound: 8	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
SK-OV-3	IC₅₀	4.4 μM Compound: 8	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
SK-OV-3	IC₅₀	5.3 μM Compound: 8	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
UACC-903	IC₅₀	2.9 μM Compound: 8	Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
UACC-903	IC₅₀	24.3 μM Compound: 8	Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
UACC-903	IC₅₀	4 μM Compound: 8	Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]

Chemical Information

CAS No. 1850293-95-6
Masse moléculaire 311.20
Formule C₁₂H₁₂N₂O₃Se
SMILES

O=C(OC1=CC=CC=C1C(NCC[Se]C#N)=O)C
Synonyms

Selenium-acetylsalicylic acid
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Plano D, et al. Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents. J Med Chem. 2016 Mar 10;59(5):1946-59. [Content Brief]

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Se-Aspirin

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Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Se-Aspirin Related Classifications

HY-117429 Related Classifications