Sec61-IN-5
Sec61-IN-5 (Compound 16c) is a Sec61 inhibitor. Sec61 shows cytotoxicity in A549 cells (IC50: 0.27 nM). Sec61-IN-5 inhibits Sec61-dependent secretory function (IC50: 0.08 nM).
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- Formule: C70H113N11O14
- Masse moléculaire:1332.71
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
0.27 nM
Compound: 16c
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Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
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[PMID: 37849553] |
| HCT-116 | CC50 |
0.8 nM
Compound: 16c
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Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
| NHDF | CC50 |
0.38 nM
Compound: 16c
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Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
| U-87MG ATCC | CC50 |
0.6 nM
Compound: 16c
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Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
| U-87MG ATCC | IC50 |
0.08 nM
Compound: 16c
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Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
Chemical Information
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Masse moléculaire 1332.71
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Formule C70H113N11O14
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SMILES
CN(C)[C@H](C(O[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(N(C)[C@H](C(N(C)[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@H](C(N[C@H](C1=O)CC2=CC=C(C=C2)C3=CC=CC=C3)=O)CC(C)C)=O)C)=O)=O)COC)=O)[C@H](NC([C@@H](C)N1C)=O)C)=O)=O)COC)C)=O)C(C)C)=O)C(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sec61-IN-5 Related Classifications
HY-156355 Related Classifications
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