SPOP-IN-2
Based on 1 Customer Validation
SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC50 of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC.
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- Pureté: 91.00%
- CAS No.: 3031640-86-2
- Formule: C15H13ClN2O5S
- Masse moléculaire:368.79
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Activité biologique
SPOP-IN-2 (0-40 μM) binds to SPOPMATH protein through competition with puc-SBC1 peptide, disrupts the interaction between SPOPMATH and Myc-PTEN or Myc-DUSP7[1].
SPOP-IN-2 (0-50 μM) selectively inhibits the colony formation of ccRCC in cell lines OS-RC-2, 786-O, A498, and 769-P[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:293T
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Concentration:0-40 μM
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Incubation Time:2 h
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Result:Decreased Myc-PTEN and Myc-DUSP7 in a dose-dependent manner.
Chemical Information
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CAS No. 3031640-86-2
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Appearance Solid
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Masse moléculaire 368.79
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Formule C15H13ClN2O5S
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Color Light yellow to yellow
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SMILES
O=C1[C@@H](NC(C2=CC=C(CCl)O2)=O)[C@@]3([H])SCC(C=C)=C(C(O)=O)N31
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)