Thalidomide-O-C3-azide
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Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs.
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- Pureté: 98.41%
- CAS No.: 2758432-00-5
- Formule: C16H15N5O5
- Masse moléculaire:357.32
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Chemical Information
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CAS No. 2758432-00-5
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Appearance Solid
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Masse moléculaire 357.32
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Formule C16H15N5O5
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Color White to off-white
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SMILES
[N-]=[N+]=NCCCOC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (139.93 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7986 mL | 13.9931 mL | 27.9861 mL | 69.9653 mL |
| 5 mM | 0.5597 mL | 2.7986 mL | 5.5972 mL | 13.9931 mL | |
| 10 mM | 0.2799 mL | 1.3993 mL | 2.7986 mL | 6.9965 mL | |
| 15 mM | 0.1866 mL | 0.9329 mL | 1.8657 mL | 4.6644 mL | |
| 20 mM | 0.1399 mL | 0.6997 mL | 1.3993 mL | 3.4983 mL | |
| 25 mM | 0.1119 mL | 0.5597 mL | 1.1194 mL | 2.7986 mL | |
| 30 mM | 0.0933 mL | 0.4664 mL | 0.9329 mL | 2.3322 mL | |
| 40 mM | 0.0700 mL | 0.3498 mL | 0.6997 mL | 1.7491 mL | |
| 50 mM | 0.0560 mL | 0.2799 mL | 0.5597 mL | 1.3993 mL | |
| 60 mM | 0.0466 mL | 0.2332 mL | 0.4664 mL | 1.1661 mL | |
| 80 mM | 0.0350 mL | 0.1749 mL | 0.3498 mL | 0.8746 mL | |
| 100 mM | 0.0280 mL | 0.1399 mL | 0.2799 mL | 0.6997 mL |
Thalidomide-O-C3-azide Related Classifications
HY-157510 Related Classifications
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