TREM2-IN-1
Based on 1 Customer Validation
TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206+ and CX3CR1+ immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells.
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- Pureté: 99.34%
- CAS No.: 2000236-36-0
- Formule: C46H68N2O20Pt
- Masse moléculaire:1164.12
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Activité biologique
TREM2[1]
TREM2-IN-1 (0.8 μM, 72 h) inhibits the prophase of DNA synthesis (G1 phase) and has potent proapoptotic ability in HCT-116 cells[1].
TREM2-IN-1 (1 μM, 24 h) remarkably inhibits the expression of TREM2 in the THP-1-derived macrophages[1].
IC50 (μM) of TREM2-IN-1 at 72 h against different cell lines[1]
| Complex | HCT-116 | HepG2 | PANC-1 | U87-MG | HK-2 |
| TREM2-IN-1 | 0.84 | 7.32 | 5.26 | 22.23 | 16.29 |