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Cat. No.: HY-158378

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Trivalent hydroxyarsinothricn

(Synonyms: R-AST-OH)

Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy.

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CAS No.: 3058726-63-6
Formule: C₄H₁₀AsNO₄
Masse moléculaire:211.05

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Trivalent hydroxyarsinothricn Chemical Structure

CAS No.: 3058726-63-6

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Description

Chemical Information

CAS No. 3058726-63-6
Masse moléculaire 211.05
Formule C₄H₁₀AsNO₄
SMILES

O=C(O)[C@H](N)CC[As](O)O
Synonyms

R-AST-OH
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sarkarai Nadar V, et al. Anticancer Effects of the Trivalent Organoarsenical 2-Amino-4-(dihydroxyarsinoyl) Butanoate. Organometallics. 2024 May 8;43(10):1137-1142. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Trivalent hydroxyarsinothricn

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Trivalent hydroxyarsinothricn

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Chemical Information

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Références

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Trivalent hydroxyarsinothricn Related Classifications

HY-158378 Related Classifications