3058726-63-6
Chemical Structure
Trivalent hydroxyarsinothricn
Synonym(s): R-AST-OH
- CAS No.: 3058726-63-6
- Formula:C4H10AsNO4
- Molecular Weight:211.05
InChIKey: OPHFDKSQCVCXEI-GSVOUGTGSA-N
SMILES: O=C(O)[C@H](N)CC[As](O)O
Biological Activity: Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy[1].
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Trivalent hydroxyarsinothricn | Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy. | |||||||||||||||||||||
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