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Cat. No.: HY-P11088

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VCAM1 binding peptide

VCAM1 binding peptide is a VCAM1 binder with internalization activity. VCAM1 binding peptide can be labeled with 5-FAM. VCAM1 binding peptide serves as a component of biosensing systems for visualizing in vitro VCAM1 endocytic pathways. VCAM1 binding peptide forms the research and development basis for MacroP and NAMP, PET radiotracers targeting VCAM1. VCAM1 binding peptide is applicable to studies related to atherosclerosis.

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CAS No.: 1311293-04-5
Formule: C₅₇H₉₅N₂₃O₁₆S
Masse moléculaire:1390.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

VCAM1 binding peptide Chemical Structure

CAS No.: 1311293-04-5

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

RDC Peptide

Voir tous les produits spécifiques à Isoform Radionuclide-Drug Conjugates (RDCs) :

In Vitro

The binding intensity of 5FAM-labeled VCAM1-binding peptide (10 mM; 4 h) to TNFα-treated HUVEC is higher than that to control HUVEC^[1].
⁶⁸Ga-MacroP (a VCAM1-binding peptide conjugate) binds specifically to VCAM-1 on the surface of TNF-α-stimulated HUVECs, and the activated cellular radioactive uptake is 4-fold higher than that of unstimulated control cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1311293-04-5
Masse moléculaire 1390.57
Formule C₅₇H₉₅N₂₃O₁₆S
Sequence

Val-His-Pro-Lys-Gln-His-Arg-Gly-Gly-Ser-Lys-Gly-Cys
Sequence Shortening

VHPKQHRGGSKGC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fu Y, et al. Endocytic pathway of vascular cell adhesion molecule 1 in human umbilical vein endothelial cell identified in vitro by using functionalized nontoxic fluorescent quantum dots[J]. Sensors and Actuators B: Chemical, 2019, 297: 126702.

[2]. Pastorino S, et al. Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting. Pharmaceutics. 2021;13(7):1025. Published 2021 Jul 6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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VCAM1 binding peptide

Voir tous les produits spécifiques à Isoform Radionuclide-Drug Conjugates (RDCs)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VCAM1 binding peptide Related Classifications

HY-P11088 Related Classifications